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Family With Sequence Similarity 5, Member C (FAM5C)

DBCCR1L; DBCCR1L1; DBCCR1-like protein 1; BMP/retinoic acid-inducible neural-specific protein 3

FAM5C contributes to aggressive periodontitis. Polymorphisms were identified within the FAM5C that show genetic linkage to and are associated with myocardial infarction (MI) in GENECARD. The association was confirmed in an independent CAD case-control sample and strong association with MI was identified with single nucleotide polymorphisms in the 3' end of FAM5C. FAM5C genotypes were also correlated with expression of the gene in human aorta. Expression levels of FAM5C decreased with increasing passage of proliferating aortic smooth muscle cells (SMC) suggesting a role for this molecule in smooth muscle cell proliferation and senescence.These data implicate FAM5C alleles in the risk of myocardial infarction and suggest further functional studies of FAM5C are required to identify the gene's contribution to atherosclerosis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins I163Hu01 Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies MI163Hu21 Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
PI163Hu01 Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits KEI163Hu ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Family With Sequence Similarity 5, Member C (FAM5C) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Family With Sequence Similarity 5, Member C (FAM5C) Bioactivity
Antibodies NONE Monoclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Family With Sequence Similarity 5, Member C (FAM5C) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Family With Sequence Similarity 5, Member C (FAM5C) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Family With Sequence Similarity 5, Member C (FAM5C) CLIA assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion."
Endocrinology 148:967-975(2007) [PubMed] [Europe PMC] [Abstract]

"Genetic and functional association of FAM5C with myocardial infarction."
BMC Med. Genet. 9:33-33(2008) [PubMed] [Europe PMC] [Abstract]

"Expression of the FAM5C in tongue squamous cell carcinoma."
Oncol. Rep. 22:1005-1011(2009) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]