Lipocalin 5 (LCN5)

E-RABP; Mep10; Epididymal-specific lipocalin-5; Epididymal retinoic acid-binding; Epididymal secretory protein 10

SPN	H911
MGI	1277241
PubMed	16414179
RGD	69320
UniProt	A2AJB7

Lipocalin 5belonging to the epididymis-specific lipocalin gene cluster. Both the 5 kb promoter fragment of the Lcn5 gene and the 5.3 kb promoter fragment of the Lcn8 gene can direct transgene expression in the epididymis, indicating that these promoter fragments contain important cis-regulatory element(s) for epididymis-specific gene expression. the Lcn5 promoter was examined in transgenic mice and immortalized epididymal cell lines. After serial deletion, the 1.8 kb promoter fragment of the Lcn5 gene was sufficient for tissue-specific and region-specific gene expression in transgenic mice.Immunohistochemistry indicated a restricted expression of Foxa2 in the epididymis where endogenous Lcn5 gene expression is suppressed and that the Foxa2 inhibition of the Lcn5 promoter is consistent with the lack of expression of Lcn5 in the corpus and cauda.

Reference

"Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid."
Endocrinology 139:2971-2981(1998) [PubMed] [Europe PMC] [Abstract].

"The transcriptional landscape of the mammalian genome."
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]. : .

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

"Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis."
Biol. Reprod. 46:747-766(1992) [PubMed] [Europe PMC] [Abstract]

Ref.5"Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis."
Biol. Reprod. 46:747-766(1992) [PubMed] [Europe PMC] [Abstract]

"Secretion and transport of mouse epididymal proteins after injection of 35S-methionine."
Biol. Reprod. 43:113-120(1990) [PubMed] [Europe PMC] [Abstract]

"The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid."
Biol. Reprod. 46:767-771(1992) [PubMed] [Europe PMC] [Abstract]

"Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry."
Proteomics 3:2221-2239(2003) [PubMed] [Europe PMC] [Abstract]