MANSC Domain Containing Protein 1 (MANSC1)

LOH12CR3; Loss of heterozygosity 12 chromosomal region 3 protein

SPN	H471
HGNC	25505
MGI	1914979
PubMed	23555315
RGD	1593458
UniProt	Q9H8J5

MANSC1 Contains 1 MANSC domain. MANSC: a seven-cysteine-containing domain present in animal membrane and extracellular proteins.

MANSC (motif at N terminus with seven cysteines) is a novel domain with a well-conserved seven-cysteine motif that is present at the N terminus of membrane and extracellular proteins, including low-density lipoprotein receptor-related protein 11 (LRP-11), hepatocyte growth factor activator inhibitor 1 (HAI-1) and some uncharacterized proteins encoded by multicellular animals from Mollusca to Chordata. the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.

Reference

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

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