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N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1)

PRED28; N6AMT; MTQ2; C21orf127; HEMK2; HemK Methyltransferase Family Member 2

N6AMT1 belongs to the methyltransferase superfamily. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
N6AMT1 was able to convert MMAIII to the less toxic dimethylarsonic acid (DMA) when overexpressed in UROtsa cells. The enhanced expression of N6AMT1 in UROtsa cells decreased cytotoxicity of both iAsIII and MMAIII. Moreover, N6AMT1 is expressed in many human tissues at variable levels, although lower than those of AS3MT, supporting a potential participation in arsenic metabolism in vivo.N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity due to its specific activity in methylating MMAIII to DMA, and other unknown mechanisms.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Hu01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Hu01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Hu01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Hu01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Hu01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Mu01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Mu01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Mu01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Mu01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Mu01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Ra01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Ra01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Ra01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Ra01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Ra01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Ca01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Ca01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Ca01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Ca01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Ca01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Po01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Po01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Po01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Po01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Po01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Bo01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Bo01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Bo01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Bo01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Bo01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Rb01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Rb01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Rb01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Rb01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Rb01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG558Mo01 Recombinant N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG558Mo01 Monoclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IP.
PAG558Mo01 Polyclonal Antibody to N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) WB; IHC; ICC; IF.
Assay Kits CLG558Mo01 CLIA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) CLIA assay for Antigen Detection
ELG558Mo01 ELISA Kit for N-6-Adenine Specific DNA Methyltransferase 1 (N6AMT1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1."
FEBS Lett. 582:2352-2356(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity."
Environ. Health Perspect. 119:771-777(2011) [PubMed] [Europe PMC] [Abstract]