Dermokine (DMKN)
Epidermis-specific secreted protein SK30/SK89
Dermokine is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This protein has been identified by Matsui et al (2004) who also suggested that this protein is a cytokine. The protein is expressed by keratinocytes in the spinous layer of the epidermis and is expressed strongly in granular keratinocytes . The protein has been found to be expressed also in tubular epithelial cells of the kidney, hepatocytes, lung macrophages, endothelial cells, acinar cells of the pancreas, smooth muscle cells, pancreatic islet cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Hu01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Hu01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Hu01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Hu01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Hu01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Mu01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Mu01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Mu01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Mu01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Mu01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Ra01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Ra01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Ra01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Ra01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Ra01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Ca01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Ca01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Ca01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Ca01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Ca01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Po01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Po01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Po01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Po01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Po01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Bo01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Bo01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Bo01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Bo01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Bo01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Rb01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Rb01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Rb01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Rb01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Rb01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG302Mo01 | Recombinant Dermokine (DMKN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG302Mo01 | Monoclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IP. |
| PAG302Mo01 | Polyclonal Antibody to Dermokine (DMKN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG302Mo01 | CLIA Kit for Dermokine (DMKN) | CLIA assay for Antigen Detection |
| ELG302Mo01 | ELISA Kit for Dermokine (DMKN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1."
Genomics 84:384-397(2004) [PubMed] [Europe PMC] [Abstract]
"The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location."
J. Invest. Dermatol. 126:503-506(2006) [PubMed] [Europe PMC] [Abstract]
"Dermokine: an extensively differentially spliced gene expressed in epithelial cells."
J. Invest. Dermatol. 127:1622-1631(2007) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]