Cell Death Inducing DFFA Like Effector C (CIDEC)
CIDE-3; Fsp27; Fat-specific protein FSP27 homolog
DNA fragmentation factor (DFF) induces the fragmentation of DNA associated with apoptosis. A novel family of cell death-inducing DFF45-like effectors (CIDEs), including CIDEC, can also promote apoptosis .
The deduced 238-amino acid protein has a predicted molecular mass of 26.8 kD and shares 44% and 38% identity with CIDEA and CIDEB, respectively. Northern blot analysis detected a 1.3-kb transcript mainly in small intestine, heart, colon, and stomach, with lower expression observed in brain, kidney, and liver. A 1.1-kb transcript was detected in placenta. The authors identified a 164-amino acid CIDEC isoform, which they called CIDE3-alpha, lacking the first N-terminal 74 amino acids. Immunofluorescence analysis localized CIDEC in a punctate manner to the cytosol.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Hu01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Hu01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Hu01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Hu01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Hu01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Mu01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Mu01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Mu01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Mu01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Mu01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Ra01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Ra01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Ra01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Ra01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Ra01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Ca01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Ca01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Ca01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Ca01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Ca01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Po01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Po01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Po01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Po01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Po01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Bo01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Bo01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Bo01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Bo01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Bo01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Rb01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Rb01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Rb01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Rb01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Rb01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG089Mo01 | Recombinant Cell Death Inducing DFFA Like Effector C (CIDEC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG089Mo01 | Monoclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IP. |
| PAG089Mo01 | Polyclonal Antibody to Cell Death Inducing DFFA Like Effector C (CIDEC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG089Mo01 | CLIA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | CLIA assay for Antigen Detection |
| ELG089Mo01 | ELISA Kit for Cell Death Inducing DFFA Like Effector C (CIDEC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family."
Biochem. J. 370:195-203(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Fat-specific protein 27 regulates storage of triacylglycerol."
J. Biol. Chem. 283:14355-14365(2008) [PubMed] [Europe PMC] [Abstract]
"Cidea is associated with lipid droplets and insulin sensitivity in humans."
Proc. Natl. Acad. Sci. U.S.A. 105:7833-7838(2008) [PubMed] [Europe PMC] [Abstract]
"Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA."
Am. J. Physiol. 297:E1395-E1413(2009) [PubMed] [Europe PMC] [Abstract]
"Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC."
EMBO Mol. Med. 1:280-287(2009) [PubMed] [Europe PMC] [Abstract]
"FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes."
Biochem. Biophys. Res. Commun. 432:296-301(2013) [PubMed] [Europe PMC] [Abstract]