BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3)
C6.1A; BRCC36; C6.1A; CXorf53; Lys-63-specific deubiquitinase BRCC36; BRCA1-A complex subunit BRCC36; BRISC complex subunit BRCC36
BRCC3 encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.
The complex showed UBC5-dependent ubiquitin E3 ligase activity. Inclusion of BRE and BRCC3 enhanced ubiquitination by the complex, and cancer-associated truncations in BRCA1 reduced the association of BRE and BRCC3 with the complex. RNA interference of BRE and BRCC3 in HeLa cells increased cell sensitivity to ionizing radiation and resulted in a defect in G2/M checkpoint arrest. the BRCC is a ubiquitin E3 ligase that enhances cellular survival following DNA damage.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Hu01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Hu01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Hu01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Hu01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Hu01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Mu01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Mu01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Mu01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Mu01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Mu01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Ra01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Ra01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Ra01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Ra01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Ra01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Ca01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Ca01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Ca01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Ca01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Ca01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Po01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Po01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Po01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Po01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Po01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Bo01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Bo01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Bo01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Bo01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Bo01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Rb01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Rb01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Rb01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Rb01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Rb01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPG075Mo01 | Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAG075Mo01 | Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IP. |
| PAG075Mo01 | Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLG075Mo01 | CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | CLIA assay for Antigen Detection |
| ELG075Mo01 | ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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