Angiopoietin Like Protein 5 (ANGPTL5)

Angiopoietin-related protein 5

SPN	F369
HGNC	19705
PubMed	19075393
UniProt	Q86XS5

The angiopoietins are a family of growth factors specific for vascular endothelium. During large-scale DNA sequencing of a human fetal brain cDNA library, Zeng et al. (2003) cloned a novel human angiopoietin-like cDNA and termed it angiopoietin-like-5 (ANGPTL5). Like other members of the angiopoietin family, the deduced 388-amino acid ANGPTL5 protein has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. RT-PCR analysis detected expression of ANGPTL5 in all tissues tested, but mainly in adult human heart.

Zeng et al. (2003) determined that the ANGPTL5 gene contains 8 exons and spans approximately 17.3 kb.By genomic sequence analysis, Zeng et al. (2003) mapped the ANGPTL5 gene to chromosome 11q22.

Reference

"Identification of a novel human angiopoietin-like gene expressed mainly in heart."
J. Hum. Genet. 48:159-162(2003) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]