Coxsackie And Adenovirus Receptor Like Membrane Protein (CLMP)

ACAM; ASAM; Adipocyte Adhesion Molecule; Adipocyte-Specific Adhesion Molecule; CXADR Like Membrane Protein

SPN	D062
HGNC	24039
MGI	1918816
PubMed	14573622
UniProt	Q9H6B4

CLMP is composed of 373 amino acids including an extracellular part containing a V- and a C2-type domain, a transmembrane region and a cytoplasmic tail. CLMP mRNA was detected in a variety of both human and mouse tissues and cell lines. The protein migrated with an Mr of around 48 on SDS-PAGE and was predominantly expressed in epithelial cells within different tissues. In cultured epithelial cells, CLMP was detected in areas of cell-cell contacts. When exogenously expressed in polarized MDCK cells, CLMP was restricted to the subapical area of the lateral cell surface, where it co-localized with the tight junction markers ZO-1 and occludin. Also endogenous CLMP showed association with tight junctions, as analyzed in polarized human CACO-2 cells.

Reference

"Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity."
Biochem. J. 387:343-353(2005) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"CLMP, a novel member of the CTX family and a new component of epithelial tight junctions."
J. Biol. Chem. 279:796-804(2004) [PubMed] [Europe PMC] [Abstract]

"CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome."
Gastroenterology 142:453-462(2012) [PubMed] [Europe PMC] [Abstract]