T-Kininogen 1 (KNT1)

Map1; T-Kinin; Thiostatin; Alpha-1-MAP; Major Acute Phase Protein

SPN	C861
PubMed	1281610
UniProt	P01048

T-kininogen, the acute phase kininogen of the rat, could be a healing protein because of its properties as a cysteine protease inhibitor. Evidence is also presented that mRNA of T-kininogen synthesis may be a function of interleukin 6 production.In rats, four types of kininogens are produced, two of which are classical high and low molecular weight kininogens and two of which are low molecular weight-like kininogens, designated T-kininogen 1 and T-kininogen 2. T-kininogen 1 and T-kininogen 2 are 430 amino acid secreted rat proteins that each contain three cystatin domains and have nearly identical functions. Existing in plasma, both T-kininogen 1 and T-kininogen 2 are glycoproteins that act as thiol protease inhibitors and also play a role in blood coagulation, specifically by helping to optimally position blood coagulation factors.

Reference

"Primary structures of the mRNAs encoding the rat precursors for bradykinin and T-kinin. Structural relationship of kininogens with major acute phase protein and alpha 1-cysteine proteinase inhibitor."
J. Biol. Chem. 260:12054-12059(1985) [PubMed] [Europe PMC] [Abstract]

"Primary structure of a gene encoding rat T-kininogen."
Gene 81:119-128(1989) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of the genes for major acute phase alpha 1-protein (thiostatin) and kininogen in the rat."
J. Biol. Chem. 262:9298-9308(1987) [PubMed] [Europe PMC] [Abstract]

"Differing utilization of homologous transcription initiation sites of rat K and T kininogen genes under inflammation condition."
J. Biol. Chem. 262:2345-2351(1987) [PubMed] [Europe PMC] [Abstract]

"Major acute phase alpha 1-protein of the rat is homologous to bovine kininogen and contains the sequence for bradykinin: its synthesis is regulated at the mRNA level."
FEBS Lett. 182:57-61(1985) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of rat T-kininogens isolated from plasma of adjuvant-treated rats. Identification of three kinds of T-kininogens."
J. Biol. Chem. 263:973-979(1988) [PubMed] [Europe PMC] [Abstract]

"Identification of a protein increasing in serum of Nagase analbuminemic rats bearing intestinal tumors as an isotype of T-kininogen."
Jpn. J. Cancer Res. 81:63-68(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of several isoforms of T-kininogen expressed in the liver of aging rats."
Arch. Biochem. Biophys. 322:333-338(1995) [PubMed] [Europe PMC] [Abstract]

"Differing expression patterns and evolution of the rat kininogen gene family."
J. Biol. Chem. 262:2190-2198(1987) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of two kinds of low molecular weight kininogens from rat (non-inflamed) plasma. One resistant and the second sensitive to rat glandular kallikreins."
J. Biol. Chem. 263:965-972(1988) [PubMed] [Europe PMC] [Abstract]