Call Now

Interferon Tau (IFNt)

IFN-T1; TP1; OTP; Trophoblastin; Interferon Tau-1; Trophoblast Protein 1; Trophoblast Antiluteolytic Protein; Antiluteolysin

Interferon tau is a Type I interferon made up of a single chain of amino-acids. In many species of ruminant, it acts as a signaling molecule during pregnancy. It is secreted by the trophoblast cells into the uterine lumen in days 13-21 of pregnancy. It decreases endometrial oxytocin receptors, which then cannot stimulate PGF-2-alpha synthesis, preventing luteolysis. It promotes uterine implantation by increasing protein synthesis in glands. Although its role in humans is not certain, it has been found to bind to the same receptors sensitive to interferon alpha, and thus may have anti-viral properties, as hinted by studies showing its ability to inhibit the reverse transcriptase enzyme found in retroviruses such as HIV. Its low toxicity compared to other interferons also supports its investigation as a potential therapeutic compound.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Hu01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Hu01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Hu01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Hu01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Hu01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Mu01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Mu01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Mu01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Mu01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Mu01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Ra01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Ra01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Ra01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Ra01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Ra01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Ca01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Ca01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Ca01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Ca01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Ca01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Po01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Po01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Po01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Po01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Po01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Bo01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Bo01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Bo01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Bo01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Bo01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Rb01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Rb01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Rb01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Rb01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Rb01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA908Mo01 Recombinant Interferon Tau (IFNt) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA908Mo01 Monoclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IP.
PAA908Mo01 Polyclonal Antibody to Interferon Tau (IFNt) WB; IHC; ICC; IF.
Assay Kits CLA908Mo01 CLIA Kit for Interferon Tau (IFNt) CLIA assay for Antigen Detection
ELA908Mo01 ELISA Kit for Interferon Tau (IFNt) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm."
Nature 330:377-379(1987) [PubMed] [Europe PMC] [Abstract]

"Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium."
Endocrinology 137:1144-1147(1996) [PubMed] [Europe PMC] [Abstract]

"Predicted structural motif of IFN tau."
Protein Eng. 7:863-867(1994) [PubMed] [Europe PMC] [Abstract]

"A three-dimensional model of interferon-tau."
J. Interferon Cytokine Res. 15:1053-1060(1995) [PubMed] [Europe PMC] [Abstract]

"IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities."
Biochimie 80:755-777(1998) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of ovine interferon-tau at 2.1 A resolution."
J. Mol. Biol. 286:151-162(1999) [PubMed] [Europe PMC] [Abstract]