Angiotensin I Converting Enzyme (ACE)
CD143; ACE1; DCP1; ACEI; ACE-I; Kininase II; Angiotensin-Converting Enzyme; Peptidyl-Dipeptidase A; Dipeptidyl Carboxypeptidase 1; Angiotensin-converting enzyme, soluble form
Angiotensin I-converting enzyme (ACE, EC 3.4.15.1), an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. ACE Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. The testis-specific isoforn is expressed in spermatocytes, adult testis. ACE can Convert angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Hu01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Hu01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Hu01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Hu01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Hu01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Mu01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Mu01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Mu01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Mu01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Mu01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Ra01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Ra01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Ra01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Ra01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Ra01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Ca01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Ca01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Ca01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Ca01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Ca01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Po01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Po01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Po01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Po01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Po01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Bo01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Bo01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Bo01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Bo01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Bo01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Rb01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Rb01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Rb01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Rb01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Rb01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW701Mo01 | Recombinant Angiotensin I Converting Enzyme (ACE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW701Mo01 | Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IP. |
| PAW701Mo01 | Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW701Mo01 | CLIA Kit for Angiotensin I Converting Enzyme (ACE) | CLIA assay for Antigen Detection |
| ELW701Mo01 | ELISA Kit for Angiotensin I Converting Enzyme (ACE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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FEBS Lett. 252:99-104(1989) [PubMed] [Europe PMC] [Abstract]
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Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
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Circ. Res. 91:749-756(2002) [PubMed] [Europe PMC] [Abstract]
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Biochem. J. 371:437-442(2003) [PubMed] [Europe PMC] [Abstract]
"ACE2 gene expression is up-regulated in the human failing heart."
BMC Med. 2:19-19(2004) [PubMed] [Europe PMC] [Abstract]
"Myocardial infarction increases ACE2 expression in rat and humans."
Eur. Heart J. 26:369-375(2005) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human angiotensin-converting enzyme-lisinopril complex."
Nature 421:551-554(2003) [PubMed] [Europe PMC] [Abstract]
"Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme."
Biochemistry 43:8718-8724(2004) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design."
J. Mol. Biol. 357:964-974(2006) [PubMed] [Europe PMC] [Abstract]
"The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM."
Clin. Nephrol. 51:133-140(1999) [PubMed] [Europe PMC] [Abstract]
"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
"Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease."
Circulation 104:1236-1240(2001) [PubMed] [Europe PMC] [Abstract]
"Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis."
Neurology 61:1819-1820(2003) [PubMed] [Europe PMC] [Abstract]
"Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls."
Arch. Neurol. 61:1652-1661(2004) [PubMed] [Europe PMC] [Abstract]
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Neurology 63:359-361(2004) [PubMed] [Europe PMC] [Abstract]
"Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."
Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]