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Growth Hormone (GH)

GH1; GH-N; GHN; hGH-N; Somatotropin; Hygetropin; Jintropin; Kigtropin; Pituitary Growth Hormone; Growth Hormone, Normal

Somatotropin is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity.

Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Hu01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Hu01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Hu01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Hu01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Hu01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Mu01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Mu01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Mu01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Mu01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Mu01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Ra01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Ra01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Ra01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Ra01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Ra01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Ca01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Ca01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Ca01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Ca01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Ca01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Po01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Po01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Po01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Po01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Po01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Bo01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Bo01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Bo01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Bo01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Bo01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Rb01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Rb01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Rb01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Rb01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Rb01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW662Mo01 Recombinant Growth Hormone (GH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW662Mo01 Monoclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IP.
PAW662Mo01 Polyclonal Antibody to Growth Hormone (GH) WB; IHC; ICC; IF.
Assay Kits CLW662Mo01 CLIA Kit for Growth Hormone (GH) CLIA assay for Antigen Detection
ELW662Mo01 ELISA Kit for Growth Hormone (GH) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and nucleotide sequence of the human growth hormone structural gene."
Nucleic Acids Res. 7:305-320(1979) [PubMed] [Europe PMC] [Abstract]

"Human growth hormone: complementary DNA cloning and expression in bacteria."
Science 205:602-607(1979) [PubMed] [Europe PMC] [Abstract]

"Human growth hormone DNA sequence and mRNA structure: possible alternative splicing."
Nucleic Acids Res. 9:3719-3730(1981) [PubMed] [Europe PMC] [Abstract]

"The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone."
DNA 1:239-249(1982) [PubMed] [Europe PMC] [Abstract]

"The human growth hormone locus: nucleotide sequence, biology, and evolution."
Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]

"Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes."
Hum. Mutat. 29:1181-1193(2008) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Periplasmic production of correctly processed human growth hormone in Escherichia coli: natural and bacterial signal sequences are interchangeable."
Gene 39:247-254(1985) [PubMed] [Europe PMC] [Abstract]

"Human pituitary growth hormone. XIX. The primary structure of the hormone."
Arch. Biochem. Biophys. 133:70-91(1969) [PubMed] [Europe PMC] [Abstract]

"Human pituitary growth hormone. 32. The primary structure of the hormone: revision."
Arch. Biochem. Biophys. 146:233-236(1971) [PubMed] [Europe PMC] [Abstract]

"Sequence comparison of human pituitary growth hormone, human chorionic somatomammotropin, and ovine pituitary growth and lactogenic hormones."
Int. J. Pept. Protein Res. 4:281-287(1972) [PubMed] [Europe PMC] [Abstract]

"Revised primary structure for human growth hormone."
Nature New Biol. 230:90-91(1971) [PubMed] [Europe PMC] [Abstract]

"Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication."
Proc. Natl. Acad. Sci. U.S.A. 68:866-869(1971) [PubMed] [Europe PMC] [Abstract]

"The chemistry of the human lactogenic hormones."
(In) Griffiths K. (eds.);Prolactin and carcinogenesis, Proc. fourth tenovus workshop prolactin, pp.13-20, Alpha Omega Alpha Press, Cardiff (1972)

"The 20,000 molecular weight variant of human growth hormone. Preparation and some physical and chemical properties."
J. Biol. Chem. 256:2395-2401(1981) [PubMed] [Europe PMC] [Abstract]

"The 20,000-dalton variant of human growth hormone: location of the amino acid deletions."
Biochem. Biophys. Res. Commun. 92:511-516(1980) [PubMed] [Europe PMC] [Abstract]

"Altered proteolytic cleavage of human growth hormone as a result of deamidation."
J. Biol. Chem. 256:11645-11650(1981) [PubMed] [Europe PMC] [Abstract]

"A new mutation causing inherited growth hormone deficiency: a compound heterozygote of a 6.7 kb deletion and a two base deletion in the third exon of the GH-1 gene."
Hum. Mol. Genet. 2:1073-1074(1993) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of phosphorylated proteins in the human pituitary."
Proteomics 4:587-598(2004) [PubMed] [Europe PMC] [Abstract]

"Growth hormone heterogeneity in human pituitary and plasma."
Horm. Res. 51 Suppl. 1:2-6(1999) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteomic analysis of the human pituitary."
Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]

"Prediction of the three-dimensional structure of human growth hormone."
Proteins 2:162-166(1987) [PubMed] [Europe PMC] [Abstract]

"Human growth hormone and extracellular domain of its receptor: crystal structure of the complex."
Science 255:306-312(1992) [PubMed] [Europe PMC] [Abstract]

"The X-ray structure of a growth hormone-prolactin receptor complex."
Nature 372:478-481(1994) [PubMed] [Europe PMC] [Abstract]

"The crystal-structure of wild-type growth-hormone at 2.5-A resolution."
Protein Pept. Lett. 2:333-340(1995)

"Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9-A resolution."
J. Biol. Chem. 271:32197-32203(1996) [PubMed] [Europe PMC] [Abstract]

"Short stature caused by a mutant growth hormone."
N. Engl. J. Med. 334:432-436(1996) [PubMed] [Europe PMC] [Abstract]

Erratum
N. Engl. J. Med. 334:1207-1207(1996)

"Detection of growth hormone gene defects by dideoxy fingerprinting (ddF)."
Endocr. J. 44:149-154(1997) [PubMed] [Europe PMC] [Abstract]

"Biologically inactive growth hormone caused by an amino acid substitution."
J. Clin. Invest. 100:1159-1165(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Autosomal dominant GH deficiency due to an Arg183His GH-1 gene mutation: clinical and molecular evidence of impaired regulated GH secretion."
J. Clin. Endocrinol. Metab. 86:3941-3947(2001) [PubMed] [Europe PMC] [Abstract]

"Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature."
Hum. Mutat. 21:424-440(2003) [PubMed] [Europe PMC] [Abstract]

"A novel dysfunctional growth hormone variant (Ile179Met) exhibits a decreased ability to activate the extracellular signal-regulated kinase pathway."
J. Clin. Endocrinol. Metab. 89:1068-1075(2004) [PubMed] [Europe PMC] [Abstract]

"Short stature caused by a biologically inactive mutant growth hormone (GH-C53S)."
J. Clin. Endocrinol. Metab. 90:2493-2499(2005) [PubMed] [Europe PMC] [Abstract]

"Evaluation of the biological activity of a growth hormone (GH) mutant (R77C) and its impact on GH responsiveness and stature."
J. Clin. Endocrinol. Metab. 92:2893-2901(2007) [PubMed] [Europe PMC] [Abstract]