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Insulin Like Growth Factor Binding Protein 1 (IGFBP1)

IBP1; AFBP; IGF-BP25; PP12; Placental Protein 12; Amniotic Fluid Binding Protein; Alpha-Pregnancy-Associated Endometrial Globulin; Growth Hormone Independent-Binding Protein

IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family ,a protein with an IGFBP domain and a thyroglobulin type-I domain. IGFBP-1 has been shown to modify the short-term effects of IGFs. Acute and chronic elevations in plasma insulin suppress the hepatic production and the circulating level of IGFBP-1, which, in turn, serve to increase the bioavailability of free IGF-I.
There is growing evidence that IGFBP-1 and the IGF/IGFBP system may form an important link between the development of hyperinsulinemia/insulin resistance and the development of cardiovascular disease. In the circulation, IGFBP-1 may prevent the adverse IGF-mediated remodeling effect on the vasculature.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Hu01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Hu01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Hu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Hu01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Hu01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Mu01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Mu01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Mu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Mu01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Mu01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Ra01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Ra01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Ra01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Ra01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Ra01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Ca01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Ca01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Ca01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Ca01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Ca01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Po01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Po01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Po01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Po01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Po01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Bo01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Bo01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Bo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Bo01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Bo01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Rb01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Rb01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Rb01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Rb01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Rb01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW655Mo01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW655Mo01 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAW655Mo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
Assay Kits CLW655Mo01 CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA assay for Antigen Detection
ELW655Mo01 ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)."
EMBO J. 7:2417-2423(1988) [PubMed] [Europe PMC] [Abstract]

"Cloning, characterization, and expression of a human insulin-like growth factor binding protein."
Biochem. Biophys. Res. Commun. 152:1289-1297(1988) [PubMed] [Europe PMC] [Abstract]

"Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin."
Nucleic Acids Res. 16:8711-8711(1988) [PubMed] [Europe PMC] [Abstract]

"Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA."
FEBS Lett. 236:295-302(1988) [PubMed] [Europe PMC] [Abstract]

"Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors."
Mol. Endocrinol. 2:404-411(1988) [PubMed] [Europe PMC] [Abstract]

"Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein."
Mol. Endocrinol. 3:846-851(1989) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene encoding the insulin-like growth factor binding protein IBP-1."
Biochem. Biophys. Res. Commun. 157:898-907(1988) [PubMed] [Europe PMC] [Abstract]

"Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7."
Genomics 12:497-502(1992) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms."
FEBS J. 276:6033-6046(2009) [PubMed] [Europe PMC] [Abstract]

"Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning."
Eur. J. Biochem. 180:259-265(1989) [PubMed] [Europe PMC] [Abstract]

"Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions."
J. Biol. Chem. 263:14203-14210(1988) [PubMed] [Europe PMC] [Abstract]

"Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability."
FEBS Lett. 291:264-268(1991) [PubMed] [Europe PMC] [Abstract]

"Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101."
J. Biol. Chem. 268:1125-1131(1993) [PubMed] [Europe PMC] [Abstract]

"The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry."
J. Biol. Chem. 274:14587-14594(1999) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid."
J. Biol. Chem. 280:29812-29819(2005) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."
Proc. Natl. Acad. Sci. U.S.A. 103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]