Insulin Like Growth Factor Binding Protein 1 (IGFBP1)
IBP1; AFBP; IGF-BP25; PP12; Placental Protein 12; Amniotic Fluid Binding Protein; Alpha-Pregnancy-Associated Endometrial Globulin; Growth Hormone Independent-Binding Protein
IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family ,a protein with an IGFBP domain and a thyroglobulin type-I domain. IGFBP-1 has been shown to modify the short-term effects of IGFs. Acute and chronic elevations in plasma insulin suppress the hepatic production and the circulating level of IGFBP-1, which, in turn, serve to increase the bioavailability of free IGF-I.
There is growing evidence that IGFBP-1 and the IGF/IGFBP system may form an important link between the development of hyperinsulinemia/insulin resistance and the development of cardiovascular disease. In the circulation, IGFBP-1 may prevent the adverse IGF-mediated remodeling effect on the vasculature.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Hu01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Hu01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Hu01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Hu01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Hu01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Mu01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Mu01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Mu01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Mu01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Mu01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Ra01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Ra01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Ra01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Ra01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Ra01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Ca01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Ca01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Ca01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Ca01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Ca01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Po01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Po01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Po01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Po01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Po01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Bo01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Bo01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Bo01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Bo01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Bo01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Rb01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Rb01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Rb01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Rb01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Rb01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW655Mo01 | Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW655Mo01 | Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IP. |
PAW655Mo01 | Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | WB; IHC; ICC; IF. | |
Assay Kits | CLW655Mo01 | CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | CLIA assay for Antigen Detection |
ELW655Mo01 | ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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FEBS Lett. 236:295-302(1988) [PubMed] [Europe PMC] [Abstract]
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Mol. Endocrinol. 2:404-411(1988) [PubMed] [Europe PMC] [Abstract]
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Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
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"The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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"Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."
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