Chromodomain Helicase DNA Binding Protein 3 (CHD3)
Mi-2a; Mi2-ALPHA; ZFH; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase
Chromodomain-helicase-DNA-binding protein 3 is a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains.
This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription.
Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Hu01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Hu01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Hu01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Hu01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Hu01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Mu01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Mu01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Mu01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Mu01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Mu01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Ra01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Ra01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Ra01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Ra01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Ra01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Ca01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Ca01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Ca01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Ca01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Ca01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Po01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Po01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Po01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Po01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Po01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Bo01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Bo01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Bo01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Bo01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Bo01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Rb01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Rb01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Rb01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Rb01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Rb01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW458Mo01 | Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW458Mo01 | Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IP. |
| PAW458Mo01 | Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 3 (CHD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW458Mo01 | CLIA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | CLIA assay for Antigen Detection |
| ELW458Mo01 | ELISA Kit for Chromodomain Helicase DNA Binding Protein 3 (CHD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family."
Eur. J. Biochem. 254:558-564(1998) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"Characterization of the CHD family of proteins."
Proc. Natl. Acad. Sci. U.S.A. 94:11472-11477(1997) [PubMed] [Europe PMC] [Abstract]
"Molecular analysis of a major antigenic region of the 240 kD protein of Mi-2 autoantigen."
J. Clin. Invest. 96:1730-1737(1995) [PubMed] [Europe PMC] [Abstract]
"Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex."
Nature 395:917-921(1998) [PubMed] [Europe PMC] [Abstract]
"Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD."
Genes Dev. 15:428-443(2001) [PubMed] [Europe PMC] [Abstract]
"Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3."
FEBS Lett. 533:14-20(2003) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity."
Mol. Biol. Cell 18:3667-3680(2007) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]