Sp100 Nuclear Antigen (Sp100)
Speckled 100 kDa; Nuclear dot-associated Sp100 protein
Sp100 nuclear antigen is an interferon stimulated antigen found in the bile duct of primary biliary cirrhosis. Histologically sp100 'dots' regions of the cell nucleus. Viral infection and mitogens affect the expression of the Sp100 autoantigen. Cells grown in the presence of interferons (α, β, and γ) revealed an increase both in size and number of the Sp100 protein-containing nuclear dots and increase the protein concentration. This raises "the question whether cytokine-mediated increase of Sp100 protein expression plays a role in induction of anti-Sp100 autoantibodies."Some sp100 variants contain a domain similar to two interferon-inducible nuclear phosphoproteins, suppressin and DEAF1. This defines a novel protein motif, the HNPP-box. Another class of variants has high mobility group 1 (HMG1) protein sequence as a domain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Hu01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Hu01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Hu01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Hu01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Hu01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Mu01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Mu01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Mu01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Mu01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Mu01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Ra01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Ra01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Ra01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Ra01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Ra01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Ca01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Ca01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Ca01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Ca01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Ca01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Po01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Po01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Po01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Po01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Po01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Bo01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Bo01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Bo01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Bo01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Bo01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Rb01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Rb01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Rb01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Rb01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Rb01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW453Mo01 | Recombinant Sp100 Nuclear Antigen (Sp100) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW453Mo01 | Monoclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IP. |
| PAW453Mo01 | Polyclonal Antibody to Sp100 Nuclear Antigen (Sp100) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW453Mo01 | CLIA Kit for Sp100 Nuclear Antigen (Sp100) | CLIA assay for Antigen Detection |
| ELW453Mo01 | ELISA Kit for Sp100 Nuclear Antigen (Sp100) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Oncogene 24:916-931(2005) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies."
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"Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program."
Cancer Res. 70:9991-10001(2010) [PubMed] [Europe PMC] [Abstract]
Erratum
Cancer Res. 73:4960-4961(2013) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Cdc20 mediates D-box-dependent degradation of Sp100."
Biochem. Biophys. Res. Commun. 415:702-706(2011) [PubMed] [Europe PMC] [Abstract]
"SP100 reduces malignancy of human glioma cells."
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J. Virol. 85:11928-11937(2011) [PubMed] [Europe PMC] [Abstract]
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]