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Protein Kinase C Delta (PKCd)

PKC-D; MAY1; PRKCD; SDK1; NPKC-Delta; Tyrosine-protein kinase PRKCD; Sphingosine-dependent protein kinase-1

  • The genes encoding the protein kinase C enzymes are widely distributed, e.g., PRKCA on chromosome 17, PRKCB1 on 16, and PRKCG on 19. Although the sequence homology among the PRKC family of genes is extensive, the pattern of expression varies among tissues. For example, the delta polypeptide appears to be the major isoform expressed in mouse hematopoietic cells. Mischak et al. (1991) isolated and characterized the mouse Prkcd gene.Aris et al. (1993) found that PKC-delta underwent calcium-independent autophosphorylation in the presence of phosphatidylserine and diacylglycerol. Diacylglycerol was an absolute requirement for PKC-delta activation. This and other cofactor and substrate requirements distinguished human PKC-delta from its mouse homolog.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Hu01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Hu01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Hu01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Hu01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Hu01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Mu01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Mu01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Mu01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Mu01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Mu01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Ra01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Ra01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Ra01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Ra01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Ra01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Ca01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Ca01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Ca01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Ca01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Ca01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Po01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Po01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Po01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Po01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Po01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Bo01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Bo01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Bo01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Bo01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Bo01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Rb01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Rb01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Rb01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Rb01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Rb01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW373Mo01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW373Mo01 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAW373Mo01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IF.
Assay Kits CLW373Mo01 CLIA Kit for Protein Kinase C Delta (PKCd) CLIA assay for Antigen Detection
ELW373Mo01 ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular and biochemical characterization of a recombinant human PKC-delta family member."
Biochim. Biophys. Acta 1174:171-181(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts."
Genes Cells 2:601-614(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel antiapoptotic human protein kinase C delta isoform, PKCdeltaVIII in NT2 cells."
Biochemistry 47:787-797(2008) [PubMed] [Europe PMC] [Abstract]

"Identification of multiple, novel, protein kinase C-related gene products."
FEBS Lett. 356:5-8(1994) [PubMed] [Europe PMC] [Abstract]

"Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta."
J. Cell. Physiol. 189:306-315(2001) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction."
Biochem. J. 361:255-265(2002) [PubMed] [Europe PMC] [Abstract]

"Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment."
Biochemistry 41:561-569(2002) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling."
J. Biol. Chem. 277:17616-17622(2002) [PubMed] [Europe PMC] [Abstract]

"Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9."
EMBO J. 22:1431-1441(2003) [PubMed] [Europe PMC] [Abstract]

"Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis."
J. Biol. Chem. 280:23643-23652(2005) [PubMed] [Europe PMC] [Abstract]

"PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation."
Blood 108:4035-4044(2006) [PubMed] [Europe PMC] [Abstract]

"Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling."
Biochem. J. 406:501-509(2007) [PubMed] [Europe PMC] [Abstract]

"Novel phosphorylation site markers of protein kinase C delta activation."
FEBS Lett. 581:3377-3381(2007) [PubMed] [Europe PMC] [Abstract]

"The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways."
Mol. Cancer Res. 5:627-639(2007) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion."
Blood 114:3056-3063(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC."
J. Leukoc. Biol. 87:153-164(2010) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C delta (PKC delta): activation mechanisms and functions."
J. Biochem. 132:831-839(2002) [PubMed] [Europe PMC] [Abstract]

"Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation."
J. Thromb. Haemost. 8:454-462(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death."
ScientificWorldJournal 10:2272-2284(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"PKC-delta and PKC-epsilon: Foes of the same family or strangers?"
J. Mol. Cell. Cardiol. 51:665-673(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Protein kinase cdelta in apoptosis: a brief overview."
Arch. Immunol. Ther. Exp. 60:361-372(2012) [PubMed] [Europe PMC] [Abstract]

"B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C delta."
Blood 121:3112-3116(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The C2 domain of PKCdelta is a phosphotyrosine binding domain."
Cell 121:271-280(2005) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the first phorbol esters/diacylglycerol binding domain of human protein kinase C, delta."
Submitted (APR-2008) to the PDB data bank