Vitamin D Receptor (VDR)
NR1I1; Nuclear Receptor Subfamily 1 Group I Member 1; Calcitriol Receptor; 1,25-dihydroxyvitamin D3 receptor
VDR is the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Hu01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Hu01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Hu01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Hu01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Hu01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Mu01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Mu01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Mu01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Mu01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Mu01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Ra01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Ra01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Ra01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Ra01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Ra01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Ca01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Ca01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Ca01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Ca01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Ca01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Po01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Po01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Po01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Po01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Po01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Bo01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Bo01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Bo01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Bo01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Bo01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Rb01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Rb01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Rb01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Rb01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Rb01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW331Mo01 | Recombinant Vitamin D Receptor (VDR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW331Mo01 | Monoclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IP. |
| PAW331Mo01 | Polyclonal Antibody to Vitamin D Receptor (VDR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW331Mo01 | CLIA Kit for Vitamin D Receptor (VDR) | CLIA assay for Antigen Detection |
| ELW331Mo01 | ELISA Kit for Vitamin D Receptor (VDR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988) [PubMed] [Europe PMC] [Abstract]
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"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
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EMBO J. 24:3881-3894(2005) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 98:5491-5496(2001) [PubMed] [Europe PMC] [Abstract]
"Structural basis of VDR-DNA interactions on direct repeat response elements."
EMBO J. 21:2242-2252(2002) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification."
J. Med. Chem. 47:1956-1961(2004) [PubMed] [Europe PMC] [Abstract]
"Structural analysis of RXR-VDR interactions on DR3 DNA."
J. Steroid Biochem. Mol. Biol. 89:215-219(2004) [PubMed] [Europe PMC] [Abstract]
"Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction."
Mol. Pharmacol. 67:1566-1573(2005) [PubMed] [Europe PMC] [Abstract]
"Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues."
J. Med. Chem. 49:5199-5205(2006) [PubMed] [Europe PMC] [Abstract]
"Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets."
Science 242:1702-1705(1988) [PubMed] [Europe PMC] [Abstract]
"A new point mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor in a kindred with hereditary 1,25-dihydroxyvitamin D-resistant rickets."
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"A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection."
Am. J. Hum. Genet. 49:668-673(1991) [PubMed] [Europe PMC] [Abstract]
"A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3."
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"Hereditary 1 alpha,25-dihydroxyvitamin D-resistant rickets resulting from a mutation in the vitamin D receptor deoxyribonucleic acid-binding domain."
J. Clin. Endocrinol. Metab. 78:313-316(1994) [PubMed] [Europe PMC] [Abstract]
"Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3."
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Clin. Genet. 65:73-76(2004) [PubMed] [Europe PMC] [Abstract]