Keratin 2 (KRT2)
KRT2A; CK2; KRTE; Cytokeratin 2; Keratin 2A; Keratin 2E; Epidermal Ichthyosis Bullosa Of Siemens; Keratin, type II cytoskeletal 2 epidermal; Epithelial keratin-2e
Keratin 2A is a type II cytokeratin, also known as Keratin 2E or Keratin 2. It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have been associated with ichthyosis bullosa of Siemens.Although the expression of KRT9 is limited to palmoplantar epidermis, KRT2 is expressed not only in this tissue but also in other regions, notably the epidermis covering the knee, thigh, and groin. It is not known whether these keratins simply replace their respective type I or type II counterpart in the preexisting KRT1/KRT10 network or dimerize with another, as yet undiscovered keratin partner. The other major epidermal keratins, KRT6 and KRT16, are normally expressed in the outer root sheath of the hair follicle and in palmoplantar epidermis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Hu01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Hu01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Hu01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Hu01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Hu01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Mu01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Mu01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Mu01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Mu01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Mu01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Ra01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Ra01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Ra01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Ra01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Ra01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Ca01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Ca01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Ca01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Ca01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Ca01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Po01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Po01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Po01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Po01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Po01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Bo01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Bo01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Bo01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Bo01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Bo01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Rb01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Rb01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Rb01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Rb01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Rb01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW316Mo01 | Recombinant Keratin 2 (KRT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW316Mo01 | Monoclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IP. |
| PAW316Mo01 | Polyclonal Antibody to Keratin 2 (KRT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW316Mo01 | CLIA Kit for Keratin 2 (KRT2) | CLIA assay for Antigen Detection |
| ELW316Mo01 | ELISA Kit for Keratin 2 (KRT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Exp. Cell Res. 202:132-141(1992) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and fine mapping of the keratin 2e gene (KRT2E): K2e V1 domain polymorphism and novel mutations in ichthyosis bullosa of Siemens."
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J. Invest. Dermatol. 103:277-281(1994) [PubMed] [Europe PMC] [Abstract]
"Ichthyosis bullosa of Siemens is caused by mutations in the keratin 2e gene."
J. Invest. Dermatol. 103:286-289(1994) [PubMed] [Europe PMC] [Abstract]
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"A novel threonine-to-proline mutation at the end of 2B rod domain in the keratin 2e chain in ichthyosis bullosa of Siemens."
J. Invest. Dermatol. 109:116-118(1997) [PubMed] [Europe PMC] [Abstract]
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Acta Derm. Venereol. 78:417-419(1998) [PubMed] [Europe PMC] [Abstract]
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Br. J. Dermatol. 140:689-695(1999) [PubMed] [Europe PMC] [Abstract]
"A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens."
J. Invest. Dermatol. 112:380-382(1999) [PubMed] [Europe PMC] [Abstract]
"Ichthyosis bullosa of Siemens resulting from a novel missense mutation near the helix termination motif of the keratin 2e gene."
Clin. Exp. Dermatol. 24:412-415(1999) [PubMed] [Europe PMC] [Abstract]
"A novel mutation in the 2B domain of keratin 2e causing ichthyosis bullosa of Siemens."
Clin. Exp. Dermatol. 25:648-651(2000) [PubMed] [Europe PMC] [Abstract]
"Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens."
Exp. Dermatol. 9:11-15(2000) [PubMed] [Europe PMC] [Abstract]
"A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens."
J. Invest. Dermatol. 114:193-195(2000) [PubMed] [Europe PMC] [Abstract]
"New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens."
Br. J. Dermatol. 145:330-335(2001) [PubMed] [Europe PMC] [Abstract]
"Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing."
Br. J. Dermatol. 152:1353-1356(2005) [PubMed] [Europe PMC] [Abstract]