Protein Kinase D1 (PKD1)
PRKD1; PRK-D1; PKC-MU; PKCM; PK-D1; PRKCM; Protein Kinase C,Mu
By screening a placenta cDNA library using a PCR fragment derived from the second conserved domain within the catalytic site of ser/thr protein kinases, Johannes et al. obtained a full-length cDNA encoding PKC-mu. The deduced 912-amino acid PRKCM protein has a calculated molecular mass of 102 kD. PRKCM has 2 characteristic cysteine-rich repeats, which are conserved among nearly all members of the PKC family, a conserved ATP-binding consensus sequence in the kinase domain, and the invariate aspartate essential for kinase activity. Northern blot analysis detected a single PRKCM transcript of 3.8 kb at low, constitutive levels in all tissues examined. The authors verified PRKCM kinase activity by transfection of a PRKCM expression vector and detecting changes in protein phosphorylation patterns by Western blot analysis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Hu01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Hu01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Hu01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Hu01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Hu01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Mu01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Mu01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Mu01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Mu01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Mu01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Ra01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Ra01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Ra01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Ra01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Ra01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Ca01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Ca01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Ca01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Ca01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Ca01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Po01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Po01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Po01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Po01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Po01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Bo01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Bo01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Bo01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Bo01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Bo01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Rb01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Rb01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Rb01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Rb01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Rb01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW300Mo01 | Recombinant Protein Kinase D1 (PKD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW300Mo01 | Monoclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IP. |
| PAW300Mo01 | Polyclonal Antibody to Protein Kinase D1 (PKD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW300Mo01 | CLIA Kit for Protein Kinase D1 (PKD1) | CLIA assay for Antigen Detection |
| ELW300Mo01 | ELISA Kit for Protein Kinase D1 (PKD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Cell 136:235-248(2009) [PubMed] [Europe PMC] [Abstract]
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Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis."
Mol. Cells 28:1-5(2009) [PubMed] [Europe PMC] [Abstract]
"Protein kinase D signaling: multiple biological functions in health and disease."
Physiology (Bethesda) 26:23-33(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
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Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]