A Disintegrin And Metalloprotease 10 (ADAM10)

CD156-C; CD156c; MADM; Kuz; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease

SPN	W046
HGNC	188
MGI	109548
PubMed	21205794
RGD	2032
UniProt	O14672
Wiki	ADAM10

A Disintegrin And Metalloprotease 10 is a ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 is a sheddase, and has a broad specificity for peptide hydrolysis reactions. New data on the ADAM10 shedding of ephrin/eph complex associated with Eph on one cell surface has determined that ADAM10 cleaves ephrin, within the ephrin/eph complex, formed between two cell surfaces. When ephrin is freed from the opposing cell, the entire ephrin/eph complex is endocytosed. This shedding in trans had not been previously shown, but may well be involved in other shedding events.

Reference

"Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases."
J. Biol. Chem. 272:24588-24593(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types."
Biochem. J. 317:45-50(1996) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."
Biochem. Biophys. Res. Commun. 230:335-339(1997) [PubMed] [Europe PMC] [Abstract]

"ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles."
FASEB J. 17:292-294(2003) [PubMed] [Europe PMC] [Abstract]

"The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein."
J. Biol. Chem. 276:37743-37746(2001) [PubMed] [Europe PMC] [Abstract]

"ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage."
J. Histochem. Cytochem. 49:1165-1176(2001) [PubMed] [Europe PMC] [Abstract]

"Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells."
Nat. Med. 8:41-46(2002) [PubMed] [Europe PMC] [Abstract]

"Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."
Cell 123:291-304(2005) [PubMed] [Europe PMC] [Abstract]

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

"The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells."
Cell Death Differ. 14:1678-1687(2007) [PubMed] [Europe PMC] [Abstract]

"Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis."
J. Biol. Chem. 284:5662-5670(2009) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI."
J. Biol. Chem. 285:11793-11799(2010) [PubMed] [Europe PMC] [Abstract]

"Junctional adhesion molecule-C is a soluble mediator of angiogenesis."
J. Immunol. 185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Ectodomain shedding and autocleavage of the cardiac membrane protease corin."
J. Biol. Chem. 286:10066-10072(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity."
Hum. Mol. Genet. 18:3987-3996(2009) [PubMed] [Europe PMC] [Abstract]

"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]

"Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease."
Hum. Mol. Genet. 22:3524-3533(2013) [PubMed] [Europe PMC] [Abstract]

"ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function."
Neuron 80:385-401(2013) [PubMed] [Europe PMC] [Abstract]