Protease Activated Receptor 2 (PAR2)
F2RL1; F2-RL1; GPR11; PAR2; Coagulation Factor II(thrombin)receptor-Like 1; G-protein coupled receptor 11; Thrombin receptor-like 1
PAR2 is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. PAR2 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. Additionally, these receptors can be activated by exogenous proteases, such as house dust mite protein Der P9. These receptors can also be activated non-protealytically, by exogenous peptide sequences that mimic the final amino acids of the tethered ligand. Recently, potent and selective small molecule agonists for these receptors have also been discovered but are not currently widely available.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Hu01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Hu01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Hu01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Hu01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Hu01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Mu01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Mu01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Mu01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Mu01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Mu01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Ra01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Ra01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Ra01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Ra01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Ra01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Ca01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Ca01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Ca01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Ca01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Ca01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Po01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Po01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Po01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Po01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Po01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Bo01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Bo01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Bo01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Bo01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Bo01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Rb01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Rb01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Rb01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Rb01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Rb01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV959Mo01 | Recombinant Protease Activated Receptor 2 (PAR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV959Mo01 | Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IP. |
| PAV959Mo01 | Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV959Mo01 | CLIA Kit for Protease Activated Receptor 2 (PAR2) | CLIA assay for Antigen Detection |
| ELV959Mo01 | ELISA Kit for Protease Activated Receptor 2 (PAR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Am. J. Respir. Cell Mol. Biol. 28:339-346(2003) [PubMed] [Europe PMC] [Abstract]
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FASEB J. 17:1871-1885(2003) [PubMed] [Europe PMC] [Abstract]
"Expression of and functional responses to protease-activated receptors on human eosinophils."
J. Leukoc. Biol. 74:60-68(2003) [PubMed] [Europe PMC] [Abstract]
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Cell. Signal. 16:21-29(2004) [PubMed] [Europe PMC] [Abstract]
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J. Biol. Chem. 280:16076-16087(2005) [PubMed] [Europe PMC] [Abstract]
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J. Thromb. Haemost. 3:2798-2805(2005) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 102:8363-8368(2005) [PubMed] [Europe PMC] [Abstract]
"Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice."
J. Pharmacol. Sci. 98:99-102(2005) [PubMed] [Europe PMC] [Abstract]
"PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists."
Am. J. Physiol. 291:L628-L635(2006) [PubMed] [Europe PMC] [Abstract]
"Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway."
Blood 107:4440-4448(2006) [PubMed] [Europe PMC] [Abstract]
"Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis."
J. Exp. Med. 203:425-435(2006) [PubMed] [Europe PMC] [Abstract]
"Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2."
J. Biol. Chem. 282:20634-20646(2007) [PubMed] [Europe PMC] [Abstract]
"p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking."
J. Biol. Chem. 282:30246-30255(2007) [PubMed] [Europe PMC] [Abstract]
"Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2."
J. Immunol. 178:5237-5244(2007) [PubMed] [Europe PMC] [Abstract]
"Chitinase activates protease-activated receptor-2 in human airway epithelial cells."
Am. J. Respir. Cell Mol. Biol. 39:530-535(2008) [PubMed] [Europe PMC] [Abstract]
"G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes."
Cell. Signal. 20:1267-1274(2008) [PubMed] [Europe PMC] [Abstract]
"Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity."
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"Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection."
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"Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2."
J. Biol. Chem. 284:28453-28466(2009) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization."
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"Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway."
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"Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils."
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"Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis."
Ann. Rheum. Dis. 69:2051-2054(2010) [PubMed] [Europe PMC] [Abstract]
"Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - a novel paradigm for G(q/11) linked GPCRs."
Cell. Signal. 22:265-273(2010) [PubMed] [Europe PMC] [Abstract]
"Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1."
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"Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo."
Mucosal Immunol. 3:29-39(2010) [PubMed] [Europe PMC] [Abstract]
"Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-gamma on human neutrophils and monocytes."
Immunology 133:329-339(2011) [PubMed] [Europe PMC] [Abstract]
"Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor triggered ERK1/2 activation, calcium signalling, and endocytosis."
Biochem. J. 438:359-367(2011) [PubMed] [Europe PMC] [Abstract]