Call Now

Integrin Alpha 2B (ITGa2B)

CD41; CD41B; ITG-A2B; GTA; GP2B; GPIIb; HPA3; Platelet Glycoprotein IIb Of IIb/IIIa Complex; Antigen CD41

ITGA2B encodes integrin alpha chain 2b. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.The ITGA2B gene encodes platelet glycoprotein IIb, the alpha subunit of the platelet membrane adhesive protein receptor complex GPIIb/IIIa. The beta subunit, GPIIIa, is encoded by the ITGB3 gene. The GPIIb/IIIa complex belongs to the integrin class of cell adhesion molecule receptors that share a common heterodimeric structure with alpha and beta subunits.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Hu01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Hu01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Hu01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Hu01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Hu01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Mu01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Mu01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Mu01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Mu01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Mu01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Ra01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Ra01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Ra01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Ra01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Ra01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Ca01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Ca01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Ca01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Ca01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Ca01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Po01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Po01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Po01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Po01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Po01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Bo01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Bo01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Bo01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Bo01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Bo01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Rb01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Rb01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Rb01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Rb01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Rb01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV783Mo01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV783Mo01 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAV783Mo01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IF.
Assay Kits CLV783Mo01 CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA assay for Antigen Detection
ELV783Mo01 ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors."
J. Biol. Chem. 262:8476-8482(1987) [PubMed] [Europe PMC] [Abstract]

"GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs."
Mol. Biol. Rep. 14:27-33(1990) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene for platelet glycoprotein IIb."
Biochemistry 29:1232-1244(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs."
J. Biol. Chem. 265:9587-9590(1990) [PubMed] [Europe PMC] [Abstract]

"cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells. Evidence for an extensive homology to other Arg-Gly-Asp adhesion receptors."
Eur. J. Biochem. 171:87-93(1988) [PubMed] [Europe PMC] [Abstract]

"Platelet glycoprotein IIb. Chromosomal localization and tissue expression."
J. Clin. Invest. 80:1812-1817(1987) [PubMed] [Europe PMC] [Abstract]

"Isolation of the human platelet glycoprotein IIb gene and characterization of the 5' flanking region."
Biochem. Biophys. Res. Commun. 156:595-601(1988) [PubMed] [Europe PMC] [Abstract]

"Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells."
Proc. Natl. Acad. Sci. U.S.A. 83:8351-8355(1986) [PubMed] [Europe PMC] [Abstract]

"Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
Biochem. J. 279:419-425(1991) [PubMed] [Europe PMC] [Abstract]

"Thermal stability of individual domains in platelet glycoprotein IIbIIIa."
Eur. J. Biochem. 237:205-211(1996) [PubMed] [Europe PMC] [Abstract]

"Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa."
Blood 69:560-564(1987) [PubMed] [Europe PMC] [Abstract]

"Interchain and intrachain disulphide bonds in human platelet glycoprotein IIb. Localization of the epitopes for several monoclonal antibodies."
Biochem. J. 261:551-560(1989) [PubMed] [Europe PMC] [Abstract]

"Complete localization of the intrachain disulphide bonds and the N-glycosylation points in the alpha-subunit of human platelet glycoprotein IIb."
Biochem. J. 261:561-568(1989) [PubMed] [Europe PMC] [Abstract]

"Localization of an O-glycosylation site in the alpha-subunit of the human platelet integrin GPIIb/IIIa involved in Baka (HPA-3a) alloantigen expression."
FEBS Lett. 328:30-34(1993) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel truncated alphaIIb integrin."
Cancer Res. 58:4771-4775(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of the beta-chain N-terminus heterogeneity and the alpha-chain C-terminus of human platelet GPIIb. Posttranslational cleavage sites."
FEBS Lett. 272:37-40(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain."
J. Biol. Chem. 272:4651-4654(1997) [PubMed] [Europe PMC] [Abstract]

"Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton."
Biochem. J. 342:729-735(1999) [PubMed] [Europe PMC] [Abstract]

"Bidirectional transmembrane modulation of integrin alphaIIbbeta3 conformations."
J. Biol. Chem. 274:12945-12949(1999) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3."
Biochem. Biophys. Res. Commun. 369:1088-1093(2008) [PubMed] [Europe PMC] [Abstract]

"Solution structures of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain."
J. Biol. Chem. 286:17181-17192(2011) [PubMed] [Europe PMC] [Abstract]

"Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences."
Biochem. Cell Biol. 90:646-656(2012) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the activation of platelet integrin alphaIIbbeta3 by calcium- and integrin-binding protein 1."
J. Am. Chem. Soc. 134:3864-3872(2012) [PubMed] [Europe PMC] [Abstract]

"Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization."
Thromb. Haemost. 72:492-502(1994) [PubMed] [Europe PMC] [Abstract]

"Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen system."
Blood 75:2343-2348(1990) [PubMed] [Europe PMC] [Abstract]

"Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb."
J. Clin. Invest. 93:172-179(1994) [PubMed] [Europe PMC] [Abstract]

"A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex."
J. Biol. Chem. 269:4450-4457(1994) [PubMed] [Europe PMC] [Abstract]

"Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association."
J. Clin. Invest. 95:1553-1560(1995) [PubMed] [Europe PMC] [Abstract]

"Glanzmann thrombasthenia due to a two amino acid deletion in the fourth calcium-binding domain of alpha IIb: demonstration of the importance of calcium-binding domains in the conformation of alpha IIb beta 3."
Blood 88:167-173(1996) [PubMed] [Europe PMC] [Abstract]

"Hematologically important mutations: Glanzmann thrombasthenia."
Blood Cells Mol. Dis. 23:39-51(1997) [PubMed] [Europe PMC] [Abstract]

"Glycoprotein IIb Leu214Pro mutation produces Glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPIIb/IIIa."
Blood 91:1562-1571(1998) [PubMed] [Europe PMC] [Abstract]

"A Gln747-->Pro substitution in the IIb subunit is responsible for a moderate IIbbeta3 deficiency in Glanzmann thrombasthenia."
Blood 92:2750-2758(1998) [PubMed] [Europe PMC] [Abstract]

"R to Q amino acid substitution in the GFFKR sequence of the cytoplasmic domain of the integrin IIb subunit in a patient with a Glanzmann's thrombasthenia-like syndrome."
Blood 92:4178-4187(1998) [PubMed] [Europe PMC] [Abstract]

"Novel point mutations in the alphaIIb subunit (Phe289-->Ser, Glu324-->Lys and Gln747-->Pro) causing thrombasthenic phenotypes in four Japanese patients."
Br. J. Haematol. 102:829-840(1998) [PubMed] [Europe PMC] [Abstract]

"Double heterozygosity of the GPIIb gene in a Swiss patient with Glanzmann's thrombasthenia."
Br. J. Haematol. 102:918-925(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular genetic analysis of a compound heterozygote for the glycoprotein (GP) IIb gene associated with Glanzmann's thrombasthenia: disruption of the 674-687 disulfide bridge in GPIIb prevents surface exposure of GPIIb-IIIa complexes."
Blood 93:866-875(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3."
Blood 95:180-188(2000) [PubMed] [Europe PMC] [Abstract]

"Description of 10 new mutations in platelet glycoprotein IIb (alphaIIb) and glycoprotein IIIa (beta3) genes."
Platelets 12:486-495(2001) [PubMed] [Europe PMC] [Abstract]

"A Leu55 to Pro substitution in the integrin alphaIIb is responsible for a case of Glanzmann's thrombasthenia."
Br. J. Haematol. 118:833-835(2002) [PubMed] [Europe PMC] [Abstract]

"Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients."
Thromb. Haemost. 87:1034-1042(2002) [PubMed] [Europe PMC] [Abstract]

"Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis."
Blood 101:2268-2276(2003) [PubMed] [Europe PMC] [Abstract]

"A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects."
Blood 101:3485-3491(2003) [PubMed] [Europe PMC] [Abstract]

"Triple heterozygosity in the integrin alphaIIb subunit in a patient with Glanzmann's thrombasthenia."
J. Thromb. Haemost. 2:813-819(2004) [PubMed] [Europe PMC] [Abstract]

"A novel Phe171Cys mutation in integrin alpha causes Glanzmann thrombasthenia by abrogating alphaIIbbeta3 complex formation."
J. Thromb. Haemost. 2:1167-1175(2004) [PubMed] [Europe PMC] [Abstract]

"Type II Glanzmann thrombasthenia in a compound heterozygote for the alpha IIb gene. A novel missense mutation in exon 27."
Haematologica 91:1352-1359(2006) [PubMed] [Europe PMC] [Abstract]

"AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function."
Hum. Mutat. 31:237-246(2010) [PubMed] [Europe PMC] [Abstract]

"Heterozygous ITGA2B R995W mutation inducing constitutive activation of the alphaIIbbeta3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia."
Blood 117:5479-5484(2011) [PubMed] [Europe PMC] [Abstract]