Heat Shock 70kDa Protein 9 (HSPA9)

CSA; GRP75; HSPA9B; MOT; MOT2; MTHSP75; PBP74; Mot-2; Stress-70 Protein,Mitochondrial; Mortalin,Perinuclear; 75 kDa glucose-regulated protein; Peptide-binding protein 74

SPN	V731
HGNC	5244
MGI	96245
PubMed	11187902
RGD	1311806
UniProt	P38646
Wiki	HSPA9

HSPA9contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein plays a role in the control of cell proliferation. It may also act as a chaperone.Mortal and immortal cells exhibit differential cellular localization of mortalin. All immortal human and mouse cells that have been tested are devoid of the uniformly distributed cytosolic form of the protein that is characteristic of normal cells. Senescent cultured cells were transiently induced to divide by the microinjection of anti-mortalin antibody. Expression of the cytosolic form (mot1) induced senescence of NIH 3T3 cells that normally harbor the perinuclear form (mot2), which differs from the cytosolic form by 2 amino acids.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Hu01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Hu01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Hu01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Hu01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Hu01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Mu01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Mu01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Mu01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Mu01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Mu01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Ra01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Ra01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Ra01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Ra01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Ra01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Ca01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Ca01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Ca01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Ca01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Ca01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Po01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Po01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Po01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Po01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Po01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Bo01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Bo01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Bo01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Bo01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Bo01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Rb01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Rb01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Rb01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Rb01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Rb01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV731Mo01	Recombinant Heat Shock 70kDa Protein 9 (HSPA9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV731Mo01	Monoclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IP.
Antibodies	PAV731Mo01	Polyclonal Antibody to Heat Shock 70kDa Protein 9 (HSPA9)	WB; IHC; ICC; IF.
Assay Kits	CLV731Mo01	CLIA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	CLIA assay for Antigen Detection
Assay Kits	ELV731Mo01	ELISA Kit for Heat Shock 70kDa Protein 9 (HSPA9)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family."
Mol. Cell. Biol. 13:3598-3610(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning and subcellular localization of human mitochondrial hsp70."
J. Biol. Chem. 270:1705-1710(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A two-dimensional gel database of human colon carcinoma proteins."
Electrophoresis 18:605-613(1997) [PubMed] [Europe PMC] [Abstract]

"Analysis of proteins from human breast epithelial cells using two-dimensional gel electrophoresis."
Electrophoresis 16:1215-1224(1995) [PubMed] [Europe PMC] [Abstract]

"Human liver protein map: a reference database established by microsequencing and gel comparison."
Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]

"Human liver protein map: update 1993."
Electrophoresis 14:1216-1222(1993) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones."
Hum. Mol. Genet. 16:929-941(2007) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis."
Hum. Mol. Genet. 19:3816-3834(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The first identification of lysine malonylation substrates and its regulatory enzyme."
Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]

"MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]

"Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization."
Mol. Cell. Proteomics 11:M111.013680.01-M111.013680.15(2012) [PubMed] [Europe PMC] [Abstract]

"Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux."
Biochem. Biophys. Res. Commun. 433:322-326(2013) [PubMed] [Europe PMC] [Abstract]

"Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone."
Int. J. Biol. Macromol. 56:140-148(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]