Alkaline Phosphatase, Liver/Bone/Kidney (ALPL)

BALP; BSAP; HOPS; AP-TNAP; TNSALP; Bone Alkaline Phosphatase; Alkaline Phosphatase,Tissue-Nonspecific Isozyme

SPN	V722
HGNC	438
MGI	87983
PubMed	3174660
RGD	2100
UniProt	P05186
Wiki	ALPL

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme encoded by the ALPL gene.There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development.

Reference

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