Myosin Light Chain Kinase (MYLK)
KRP; MLCK108; MLCK210; MSTP083; MLCK; smMLCK; MYLK1; MLCK1; Telokin; Myosin Light Chain Kinase, Smooth Muscle, deglutamylated form; Kinase-related protein
Myosin light chain kinase, smooth muscle is a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity.
This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Hu01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Hu01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Hu01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Hu01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Hu01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Mu01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Mu01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Mu01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Mu01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Mu01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Ra01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Ra01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Ra01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Ra01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Ra01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Ca01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Ca01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Ca01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Ca01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Ca01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Po01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Po01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Po01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Po01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Po01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Bo01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Bo01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Bo01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Bo01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Bo01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Rb01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Rb01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Rb01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Rb01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Rb01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV707Mo01 | Recombinant Myosin Light Chain Kinase (MYLK) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV707Mo01 | Monoclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IP. |
PAV707Mo01 | Polyclonal Antibody to Myosin Light Chain Kinase (MYLK) | WB; IHC; ICC; IF. | |
Assay Kits | CLV707Mo01 | CLIA Kit for Myosin Light Chain Kinase (MYLK) | CLIA assay for Antigen Detection |
ELV707Mo01 | ELISA Kit for Myosin Light Chain Kinase (MYLK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Acta Pharmacol. Sin. 31:725-732(2010) [PubMed] [Europe PMC] [Abstract]
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Mol. Biol. Cell 21:4042-4056(2010) [PubMed] [Europe PMC] [Abstract]
"The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase."
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"Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury."
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Submitted (NOV-2005) to the PDB data bank
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