Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4)
CD152; CELIAC3; CTLA4; GSE; IDDM12; Celiac Disease 3; Cytotoxic T-lymphocyte protein 4
CTLA4 is a protein that plays an important regulatory role in the immune system. In humans, the CTLA4 protein is encoded by the CTLA4 gene.CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells.
CTLA4 is similar to the T-cell costimulatory protein CD28, and both molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Hu01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Hu01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Hu01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Hu01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Hu01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Mu01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Mu01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Mu01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Mu01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Mu01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Ra01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Ra01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Ra01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Ra01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Ra01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Ca01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Ca01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Ca01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Ca01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Ca01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Po01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Po01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Po01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Po01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Po01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Bo01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Bo01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Bo01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Bo01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Bo01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Rb01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Rb01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Rb01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Rb01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Rb01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV596Mo01 | Recombinant Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV596Mo01 | Monoclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IP. |
| PAV596Mo01 | Polyclonal Antibody to Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV596Mo01 | CLIA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | CLIA assay for Antigen Detection |
| ELV596Mo01 | ELISA Kit for Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location."
J. Immunol. 147:1037-1044(1991) [PubMed] [Europe PMC] [Abstract]
"Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."
Genomics 78:155-168(2001) [PubMed] [Europe PMC] [Abstract]
"Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis."
Clin. Immunol. 128:374-381(2008) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains."
Eur. J. Immunol. 18:1901-1905(1988) [PubMed] [Europe PMC] [Abstract]
"Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders."
Genomics 60:341-355(1999) [PubMed] [Europe PMC] [Abstract]
"CTLA-4 is a second receptor for the B cell activation antigen B7."
J. Exp. Med. 174:561-569(1991) [PubMed] [Europe PMC] [Abstract]
"Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2."
Immunity 6:583-589(1997) [PubMed] [Europe PMC] [Abstract]
"Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4."
Biochem. Biophys. Res. Commun. 252:14-19(1998) [PubMed] [Europe PMC] [Abstract]
"Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4."
J. Cell. Biochem. 78:241-250(2000) [PubMed] [Europe PMC] [Abstract]
"Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease."
Nature 423:506-511(2003) [PubMed] [Europe PMC] [Abstract]
"Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation."
J. Immunol. 175:996-1004(2005) [PubMed] [Europe PMC] [Abstract]
"A molecular perspective of CTLA-4 function."
Annu. Rev. Immunol. 24:65-97(2006) [PubMed] [Europe PMC] [Abstract]
"CTLA-4 trafficking and surface expression."
Trends Immunol. 29:272-279(2008) [PubMed] [Europe PMC] [Abstract]
"The clinical utility of inhibiting CD28-mediated costimulation."
Immunol. Rev. 229:307-321(2009) [PubMed] [Europe PMC] [Abstract]
"Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28."
Nat. Struct. Biol. 4:527-531(1997) [PubMed] [Europe PMC] [Abstract]
"Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."
Nature 410:604-608(2001) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses."
Nature 410:608-611(2001) [PubMed] [Europe PMC] [Abstract]
"Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering."
J. Biol. Chem. 286:6685-6696(2011) [PubMed] [Europe PMC] [Abstract]
"Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups."
Hum. Mol. Genet. 6:1275-1282(1997) [PubMed] [Europe PMC] [Abstract]
"CTLA-4 gene polymorphism is associated with predisposition to coeliac disease."
Gut 43:187-189(1998) [PubMed] [Europe PMC] [Abstract]
"Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy."
Lancet 354:743-744(1999) [PubMed] [Europe PMC] [Abstract]
"Complex association analysis of Graves disease using a set of polymorphic markers."
Mol. Genet. Metab. 70:214-218(2000) [PubMed] [Europe PMC] [Abstract]
"Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene."
Am. J. Hum. Genet. 67:737-744(2000) [PubMed] [Europe PMC] [Abstract]
"Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus."
Eur. J. Hum. Genet. 12:620-626(2004) [PubMed] [Europe PMC] [Abstract]
"Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection."
J. Virol. 78:11258-11262(2004) [PubMed] [Europe PMC] [Abstract]
"A common CTLA4 haplotype associated with coeliac disease."
Eur. J. Hum. Genet. 13:440-444(2005) [PubMed] [Europe PMC] [Abstract]
"CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis."
Hum. Genet. 116:361-367(2005) [PubMed] [Europe PMC] [Abstract]
"Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations."
Nat. Med. 20:1410-1416(2014) [PubMed] [Europe PMC] [Abstract]
"Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4."
Science 345:1623-1627(2014) [PubMed] [Europe PMC] [Abstract]