Apoptosis Signal Regulating Kinase 1 (ASK1)
MAP3-K5; MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-Activated Protein Kinase Kinase Kinase 5; MAPK/ERK kinase kinase 5
Apoptosis signal-regulating kinase 1 is an enzyme which in humans is encoded by the MAP3K5 gene. This gene is located on chromosome 6 at locus 6q22.33 and the transcribed protein contains 1,374 amino acids with 11 kinase subdomains. The ASK1 (MAPKKK5) protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; ASK1 does not activate MAPK/ERK.ASK1 found in the inactive form, bound to reduced thioredoxin.
When oxidized by a reactive oxygen species, Trx dissociates from ASK1. The ASK1, which is found as a homo-oligodimer, autophosphorylates and becomes an active MAP kinase kinase kinase.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Hu01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Hu01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Hu01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Hu01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Hu01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Mu01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Mu01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Mu01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Mu01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Mu01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Ra01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Ra01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Ra01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Ra01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Ra01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Ca01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Ca01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Ca01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Ca01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Ca01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Po01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Po01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Po01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Po01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Po01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Bo01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Bo01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Bo01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Bo01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Bo01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Rb01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Rb01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Rb01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Rb01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Rb01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV475Mo01 | Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV475Mo01 | Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IP. |
| PAV475Mo01 | Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV475Mo01 | CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | CLIA assay for Antigen Detection |
| ELV475Mo01 | ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
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