Immunoglobulin Associated Beta (Igb)

CD79b; B29; Immunoglobulin-associated B29 protein; B-cell antigen receptor complex-associated protein beta chain

SPN	V451
HGNC	1699
MGI	96431
PubMed	10516749
RGD	620012
UniProt	P40259
Wiki	CD79B

Immunoglobulin-associated beta, The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor.

This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.The deduced 229-amino acid protein has a hydrophobic leader sequence, an Ig-like domain, a positively charged extracellular domain, a transmembrane domain, and an intracytoplasmic tail containing a motif present in molecules involved in lymphocyte activation. Human and mouse B29 share 75% amino acid identity.

Reference

"Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29."
Eur. J. Immunol. 22:1621-1625(1992) [PubMed] [Europe PMC] [Abstract]

"Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)."
Genomics 16:187-192(1993) [PubMed] [Europe PMC] [Abstract]

"The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes."
J. Immunol. 150:491-498(1993) [PubMed] [Europe PMC] [Abstract]

"The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism."
Immunogenetics 40:145-149(1994) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells."
Mol. Immunol. 32:651-659(1995) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex."
Mol. Immunol. 31:419-427(1994) [PubMed] [Europe PMC] [Abstract]

"Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex."
J. Biol. Chem. 271:5158-5163(1996) [PubMed] [Europe PMC] [Abstract]

"B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta."
Blood 89:1513-1520(1997) [PubMed] [Europe PMC] [Abstract]

"B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta."
J. Immunol. 169:865-872(2002) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor."
Structure 18:934-943(2010) [PubMed] [Europe PMC] [Abstract]

"A hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development."
J. Immunol. 179:2055-2059(2007) [PubMed] [Europe PMC] [Abstract]