Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1)
MP1; MAPBP; MAP2K1IP1; LAMTOR3; Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
Mitogen-activated protein kinase scaffold protein 1 is an enzyme identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade. When overexpressed in cultured cells, MP1 enhanced activation of ERK1 and activation of a reporter driven by the transcription factor ELK1. Expression of MP1 in cells increased binding of ERK1 to MEK1. MP1 apparently functions as an adaptor to enhance the efficiency of the MAP kinase cascade. The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in disease.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Hu01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Hu01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Hu01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Hu01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Hu01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Mu01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Mu01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Mu01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Mu01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Mu01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Ra01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Ra01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Ra01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Ra01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Ra01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Ca01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Ca01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Ca01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Ca01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Ca01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Po01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Po01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Po01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Po01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Po01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Bo01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Bo01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Bo01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Bo01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Bo01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Rb01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Rb01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Rb01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Rb01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Rb01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV389Mo01 | Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV389Mo01 | Monoclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IP. |
| PAV389Mo01 | Polyclonal Antibody to Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV389Mo01 | CLIA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | CLIA assay for Antigen Detection |
| ELV389Mo01 | ELISA Kit for Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids."
Cell 141:290-303(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1."
Cell 150:1196-1208(2012) [PubMed] [Europe PMC] [Abstract]
"SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1."
Nature 519:477-481(2015) [PubMed] [Europe PMC] [Abstract]
"Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1."
Science 347:188-194(2015) [PubMed] [Europe PMC] [Abstract]
"The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal MAP kinase signaling."
J. Biol. Chem. 279:23422-23430(2004) [PubMed] [Europe PMC] [Abstract]