Peptidylprolyl Isomerase E (PPIE)
PPI-E; CYP-33; PPIase E; Peptidyl Prolyl Cis/Trans Isomerase E; Cyclophilin E; Cyclophilin-33; Rotamase E
Peptidyl-prolyl cis-trans isomerase E is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities and also exhibit RNA-binding activity. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.
The PPIase activity of CYP33 is inhibited by CsA with kinetics similar to other CYPs. Northern blotting of T-cell mRNA revealed expression of a low abundance 1.6-kb CYP33 transcript.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Hu01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Hu01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Hu01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Hu01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Hu01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Mu01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Mu01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Mu01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Mu01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Mu01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Ra01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Ra01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Ra01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Ra01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Ra01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Ca01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Ca01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Ca01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Ca01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Ca01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Po01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Po01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Po01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Po01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Po01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Bo01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Bo01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Bo01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Bo01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Bo01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Rb01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Rb01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Rb01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Rb01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Rb01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV341Mo01 | Recombinant Peptidylprolyl Isomerase E (PPIE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV341Mo01 | Monoclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IP. |
| PAV341Mo01 | Polyclonal Antibody to Peptidylprolyl Isomerase E (PPIE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV341Mo01 | CLIA Kit for Peptidylprolyl Isomerase E (PPIE) | CLIA assay for Antigen Detection |
| ELV341Mo01 | ELISA Kit for Peptidylprolyl Isomerase E (PPIE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines."
Oncogene 17:1019-1026(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A nuclear RNA-binding cyclophilin in human T cells."
FEBS Lett. 398:201-205(1996) [PubMed] [Europe PMC] [Abstract]
"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
"Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair."
J. Biol. Chem. 283:940-950(2008) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the RNA recognition motif in peptidyl-prolyl cis-trans isomerase E."
Submitted (NOV-2005) to the PDB data bank