Killer Cell Lectin Like Receptor Subfamily C, Member 2 (KLRC2)

CD159c; NKG2C; NKG2-C Type II Integral Membrane Protein; CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor

SPN	V326
HGNC	6375
MGI	1336162
PubMed	14688071
RGD	2977
UniProt	P26717
Wiki	KLRC2

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC are expressed primarily in natural killer cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation  and the presence of a C-type lectin domain. The KLRC gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.

Reference

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J. Exp. Med. 173:1017-1020(1991) [PubMed] [Europe PMC] [Abstract]

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