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Peptidylprolyl Isomerase F (PPIF)

PPI-F; CYP3; Cyp-D; CyP-M; Peptidyl-Prolyl Cis-Trans Isomerase,Mitochondrial; Cyclophilin F; Mitochondrial cyclophilin; Rotamase F

Peptidyl-prolyl cis-trans isomerase, mitochondrial is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.Northern blot analysis showed that PPIF, which the authors termed CYP3, is expressed as a major 2-kb transcript in Jurkat cells. RNA slot blot analysis revealed expression of PPIF in most cell lines and types. Western blot analysis of Jurkat cells separated by differential centrifugation suggested that PPIF is predominantly associated with membranes or organelles.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Hu01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Hu01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Hu01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Hu01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Hu01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Mu01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Mu01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Mu01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Mu01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Mu01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Ra01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Ra01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Ra01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Ra01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Ra01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Ca01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Ca01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Ca01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Ca01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Ca01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Po01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Po01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Po01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Po01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Po01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Bo01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Bo01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Bo01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Bo01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Bo01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Rb01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Rb01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Rb01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Rb01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Rb01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV285Mo01 Recombinant Peptidylprolyl Isomerase F (PPIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV285Mo01 Monoclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IP.
PAV285Mo01 Polyclonal Antibody to Peptidylprolyl Isomerase F (PPIF) WB; IHC; ICC; IF.
Assay Kits CLV285Mo01 CLIA Kit for Peptidylprolyl Isomerase F (PPIF) CLIA assay for Antigen Detection
ELV285Mo01 ELISA Kit for Peptidylprolyl Isomerase F (PPIF) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms."
J. Biol. Chem. 266:23204-23214(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Import and processing of heart mitochondrial cyclophilin D."
Eur. J. Biochem. 263:353-359(1999) [PubMed] [Europe PMC] [Abstract]

"Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect."
J. Biol. Chem. 284:9692-9699(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death."
Biochem. J. 433:119-125(2011) [PubMed] [Europe PMC] [Abstract]

"Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore."
J. Biol. Chem. 286:40184-40192(2011) [PubMed] [Europe PMC] [Abstract]

"p53 opens the mitochondrial permeability transition pore to trigger necrosis."
Cell 149:1536-1548(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 A resolution."
Acta Crystallogr. D 61:513-519(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution."
Proteins 70:1635-1639(2008) [PubMed] [Europe PMC] [Abstract]

"In-plate protein crystallization, in situ ligand soaking and X-ray diffraction."
Acta Crystallogr. D 67:747-755(2011) [PubMed] [Europe PMC] [Abstract]