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Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3)

MAPKAPK3; 3PK; MK-3; Chromosome 3p kinase

MAPKAPK3 functions as a mitogen-activated protein kinase (MAP kinase)-activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Hu01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Hu01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Hu01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Hu01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Mu01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Mu01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Mu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Mu01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Mu01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Ra01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Ra01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Ra01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Ra01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Ra01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Ca01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Ca01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Ca01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Ca01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Ca01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Po01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Po01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Po01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Po01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Po01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Bo01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Bo01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Bo01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Bo01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Bo01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Rb01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Rb01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Rb01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Rb01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Rb01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV204Mo01 Recombinant Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV204Mo01 Monoclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IP.
PAV204Mo01 Polyclonal Antibody to Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) WB; IHC; ICC; IF.
Assay Kits CLV204Mo01 CLIA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) CLIA assay for Antigen Detection
ELV204Mo01 ELISA Kit for Mitogen Activated Protein Kinase Activated Protein Kinase 3 (MAPKAPK3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase."
J. Biol. Chem. 271:8488-8492(1996) [PubMed] [Europe PMC] [Abstract]

"3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region."
Mol. Cell. Biol. 16:868-876(1996) [PubMed] [Europe PMC] [Abstract]

Erratum
Mol. Cell. Biol. 16:1880-1880(1996)

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress."
FEBS Lett. 392:209-214(1996) [PubMed] [Europe PMC] [Abstract]

"Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation."
J. Biol. Chem. 274:18947-18956(1999) [PubMed] [Europe PMC] [Abstract]

"Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity."
J. Biol. Chem. 275:20239-20242(2000) [PubMed] [Europe PMC] [Abstract]

"Mitogen-activated 3p kinase is active in the nucleus."
Exp. Cell Res. 299:101-109(2004) [PubMed] [Europe PMC] [Abstract]

"MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1."
J. Biol. Chem. 280:5178-5187(2005) [PubMed] [Europe PMC] [Abstract]

"Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex."
Biochem. J. 409:711-722(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin."
Biochem. Pharmacol. 80:1915-1920(2010) [PubMed] [Europe PMC] [Abstract]

"MK2 and MK3--a pair of isoenzymes?"
Front. Biosci. 13:5511-5521(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand."
Protein Sci. 19:168-173(2010) [PubMed] [Europe PMC] [Abstract]

"Structure-based lead identification of ATP-competitive MK2 inhibitors."
Bioorg. Med. Chem. Lett. 21:3818-3822(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]