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Interleukin 12 Receptor Beta 1 (IL12Rb1)

CD212; IL12R-B1; IL12-RB1; IL-12R-Beta1; IL12RB

Interleukin 12 receptor, beta 1  is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex.

This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Hu01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Hu01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Hu01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Hu01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Hu01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Mu01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Mu01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Mu01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Mu01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Mu01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Ra01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Ra01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Ra01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Ra01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Ra01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Ca01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Ca01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Ca01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Ca01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Ca01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Po01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Po01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Po01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Po01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Po01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Bo01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Bo01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Bo01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Bo01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Bo01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Rb01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Rb01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Rb01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Rb01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Rb01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV199Mo01 Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV199Mo01 Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IP.
PAV199Mo01 Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) WB; IHC; ICC; IF.
Assay Kits CLV199Mo01 CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) CLIA assay for Antigen Detection
ELV199Mo01 ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130."
J. Immunol. 153:128-136(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."
Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]

"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]

"Interleukin-12 receptor beta-1 deficiency in a patient with abdominal tuberculosis."
J. Infect. Dis. 184:231-236(2001) [PubMed] [Europe PMC] [Abstract]