Interleukin 12 Receptor Beta 1 (IL12Rb1)
CD212; IL12R-B1; IL12-RB1; IL-12R-Beta1; IL12RB
Interleukin 12 receptor, beta 1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex.
This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Hu01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Hu01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Hu01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Hu01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Hu01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Mu01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Mu01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Mu01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Mu01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Mu01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Ra01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Ra01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Ra01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Ra01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Ra01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Ca01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Ca01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Ca01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Ca01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Ca01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Po01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Po01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Po01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Po01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Po01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Bo01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Bo01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Bo01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Bo01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Bo01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Rb01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Rb01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Rb01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Rb01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Rb01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV199Mo01 | Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV199Mo01 | Monoclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IP. |
PAV199Mo01 | Polyclonal Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1) | WB; IHC; ICC; IF. | |
Assay Kits | CLV199Mo01 | CLIA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | CLIA assay for Antigen Detection |
ELV199Mo01 | ELISA Kit for Interleukin 12 Receptor Beta 1 (IL12Rb1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."
Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]
"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]
"Interleukin-12 receptor beta-1 deficiency in a patient with abdominal tuberculosis."
J. Infect. Dis. 184:231-236(2001) [PubMed] [Europe PMC] [Abstract]