TATA Binding Protein (TBP)
GTF2D; GTF2D1; SCA17; TFIID; TATA sequence-binding protein; TATA-box factor; Transcription initiation factor TFIID TBP subunit
The TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex.
As one of the few proteins in the preinitiation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. However, it is estimated that only 10-20% of human promoters have TATA boxes. Therefore, TBP is probably not the only protein involved in positioning RNA polymerase II.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Hu01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Hu01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Hu01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Hu01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Hu01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Mu01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Mu01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Mu01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Mu01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Mu01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Ra01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Ra01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Ra01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Ra01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Ra01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Ca01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Ca01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Ca01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Ca01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Ca01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Po01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Po01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Po01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Po01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Po01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Bo01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Bo01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Bo01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Bo01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Bo01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Rb01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Rb01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Rb01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Rb01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Rb01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV136Mo01 | Recombinant TATA Binding Protein (TBP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV136Mo01 | Monoclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IP. |
| PAV136Mo01 | Polyclonal Antibody to TATA Binding Protein (TBP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV136Mo01 | CLIA Kit for TATA Binding Protein (TBP) | CLIA assay for Antigen Detection |
| ELV136Mo01 | ELISA Kit for TATA Binding Protein (TBP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Highly conserved core domain and unique N-terminus with presumptive regulatory motifs in a human TATA factor (TFIID)."
Nature 346:387-390(1990) [PubMed] [Europe PMC] [Abstract]
"Functional domains and upstream activation properties of cloned human TATA binding protein."
Science 248:1625-1630(1990) [PubMed] [Europe PMC] [Abstract]
"Cloning of a transcriptionally active human TATA binding factor."
Science 248:1646-1650(1990) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB."
J. Virol. 67:4676-4687(1993) [PubMed] [Europe PMC] [Abstract]
"The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein."
J. Biol. Chem. 269:30140-30146(1994) [PubMed] [Europe PMC] [Abstract]
"Direct interaction of human TFIID with the HIV-1 transactivator tat."
Nature 367:295-299(1994) [PubMed] [Europe PMC] [Abstract]
"Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits."
Science 266:1966-1972(1994) [PubMed] [Europe PMC] [Abstract]
"Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo."
J. Mol. Biol. 250:169-180(1995) [PubMed] [Europe PMC] [Abstract]
"Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity."
J. Biol. Chem. 273:25840-25849(1998) [PubMed] [Europe PMC] [Abstract]
"Requirement of RSF and FACT for transcription of chromatin templates in vitro."
Science 282:1900-1904(1998) [PubMed] [Europe PMC] [Abstract]
"TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."
J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
"Genomics, evolution, and expression of TBPL2, a member of the TBP family."
DNA Cell Biol. 26:369-385(2007) [PubMed] [Europe PMC] [Abstract]
"SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."
J. Biol. Chem. 274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]
"A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."
J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
"Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)."
Oncogene 18:3682-3695(1999) [PubMed] [Europe PMC] [Abstract]
"BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein."
J. Biol. Chem. 276:43056-43064(2001) [PubMed] [Europe PMC] [Abstract]
"The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger."
Mol. Cell. Biol. 21:5109-5121(2001) [PubMed] [Europe PMC] [Abstract]
"Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis."
Hum. Mol. Genet. 11:2341-2346(2002) [PubMed] [Europe PMC] [Abstract]
"The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
"HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs."
PLoS Biol. 3:221-230(2005) [PubMed] [Europe PMC] [Abstract]
"MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity."
J. Biol. Chem. 284:5165-5174(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of a human TATA box-binding protein/TATA element complex."
Proc. Natl. Acad. Sci. U.S.A. 93:4862-4867(1996) [PubMed] [Europe PMC] [Abstract]
"How proteins recognize the TATA box."
J. Mol. Biol. 261:239-254(1996) [PubMed] [Europe PMC] [Abstract]
"Structural basis of preinitiation complex assembly on human pol II promoters."
EMBO J. 19:25-36(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex."
Cell 106:71-81(2001) [PubMed] [Europe PMC] [Abstract]
"A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?"
Hum. Mol. Genet. 8:2047-2053(1999) [PubMed] [Europe PMC] [Abstract]
"Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia."
Eur. J. Hum. Genet. 9:160-164(2001) [PubMed] [Europe PMC] [Abstract]
"SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein."
Hum. Mol. Genet. 10:1441-1448(2001) [PubMed] [Europe PMC] [Abstract]
"Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus."
Arch. Neurol. 59:623-629(2002) [PubMed] [Europe PMC] [Abstract]