Regenerating Islet Derived Protein 1 Alpha (REG1a)

REG; PSP; ICRF; PSPS1; PTP; Islet cells regeneration factor; Islet of Langerhans regenerating protein; Lithostathine 1 Alpha; Pancreatic Stone Protein; Pancreatic Thread Protein

SPN	V079
HGNC	9951
MGI	97895
PubMed	15814635
RGD	3552
UniProt	P05451
Wiki	REG1A

Pancreatic stone protein is the major component of the protein matrix of calculi in patients suffering from chronic calcifying pancreatitis. Secretory pancreatic stone protein is a glycoprotein in the pancreatic secretion. This protein, called PSPS, occurs in multiple molecular forms due to posttranslational processing.

The abundance of PSPS in pancreatic juice (10 to 14% of total protein) suggests that it plays an important role in exocrine pancreatic function. In vitro experiments show that PSPS inhibits CaCO(3) crystal growth. Since in all the pancreatic secretions are supersaturated in calcium carbonate, the physiologic role of PSPS may be related to its inhibitory properties. This gene encodes a protein that is secreted by the exocrine pancreas.

Reference

"A novel gene activated in regenerating islets."
J. Biol. Chem. 263:2111-2114(1988) [PubMed] [Europe PMC] [Abstract]

"Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene."
J. Biol. Chem. 265:7432-7439(1990) [PubMed] [Europe PMC] [Abstract]

"Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis."
J. Clin. Invest. 84:100-106(1989) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice."
Eur. J. Biochem. 168:201-207(1987) [PubMed] [Europe PMC] [Abstract]

"Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein."
Biochem. J. 238:227-232(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation, characterization, and distribution of an unusual pancreatic human secretory protein."
J. Clin. Invest. 76:2115-2125(1985) [PubMed] [Europe PMC] [Abstract]

"N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue."
Biochim. Biophys. Acta 994:281-284(1989) [PubMed] [Europe PMC] [Abstract]

"Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein."
FEBS Lett. 216:195-199(1987) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"The human reg gene encodes pancreatic stone protein."
Biochem. J. 260:622-623(1989) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae."
FEBS Lett. 272:85-88(1990) [PubMed] [Europe PMC] [Abstract]

"Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain."
J. Clin. Invest. 86:1004-1013(1990) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation."
EMBO J. 15:2678-2684(1996) [PubMed] [Europe PMC] [Abstract]

"Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine."
J. Biol. Chem. 275:1057-1064(2000) [PubMed] [Europe PMC] [Abstract]

"What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy."
Protein Eng. 9:949-957(1996) [PubMed] [Europe PMC] [Abstract]