Receptor Interacting Serine Threonine Kinase 2 (RIPK2)

CCK; CARD3; CARDIAK; GIG30; RICK; RIP2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; Receptor-interacting 2; RIP-like-interacting CLARP kinase

SPN	V054
HGNC	10020
MGI	1891456
PubMed	22993319
RGD	1309167
UniProt	O43353
Wiki	RIPK2

Receptor-interacting serine/threonine-protein kinase 2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappa;B and inducer of apoptosis in response to various stimuli. Expression of RICK promoted the activation of caspase-8 and potentiated apoptosis induced by FAS, FADD, CLARP, and caspase-8. Northern blot analysis revealed that RICK is expressed in various human tissues as 2.5- and 1.8-kb mRNAs that differ due to alternative polyadenylation. The authors concluded that RICK is a novel kinase that may regulate apoptosis induced by the FAS receptor pathway.

Reference

"RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis."
J. Biol. Chem. 273:12296-12300(1998) [PubMed] [Europe PMC] [Abstract]

"RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase."
J. Biol. Chem. 273:16968-16975(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of CARDIAK, a RIP-like kinase that associates with caspase-1."
Curr. Biol. 8:885-888(1998) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation."
J. Biol. Chem. 279:1570-1574(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2."
Cell. Signal. 18:2223-2229(2006) [PubMed] [Europe PMC] [Abstract]

"Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK."
J. Mol. Biol. 365:160-174(2007) [PubMed] [Europe PMC] [Abstract]

"MEKK4 sequesters RIP2 to dictate NOD2 signal specificity."
Curr. Biol. 18:1402-1408(2008) [PubMed] [Europe PMC] [Abstract]

"A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation."
EMBO J. 27:373-383(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways."
Curr. Biol. 19:1255-1263(2009) [PubMed] [Europe PMC] [Abstract]

"Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2."
Immunity 30:789-801(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses."
Genes Dev. 24:2666-2677(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."
PLoS ONE 6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]

"NLRP10 enhances Shigella-induced pro-inflammatory responses."
Cell. Microbiol. 14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]

"Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."
Inflamm. Bowel Dis. 18:603-612(2012) [PubMed] [Europe PMC] [Abstract]

"OTULIN restricts Met1-linked ubiquitination to control innate immune signaling."
Mol. Cell 50:818-830(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]