Fibroblast Growth Factor Receptor 4 (FGFR4)

CD334; JTK2; TKF

SPN	V041
HGNC	3691
MGI	95525
PubMed	10691305
RGD	2612
UniProt	P22455
Wiki	FGFR4

Fibroblast growth factor receptor 4, also known as FGFR4, is a human gene. FGFR4 has also been designated as CD334 . The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

Reference

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