Jagged 1 Protein (JAG1)
CD339; AGS; AHD; AWS; HJ1; JAGL1; Alagille Syndrome
Jagged-1 is a ligand of the Notch receptor, and their binding triggers a cascade of proteolytic cleavage that eventually leads to the release of the intracellular part of the receptor from the membrane, allowing it to translocate to the nucleus and activate transcription factors that play key roles in cell differentiation and morphogenesis
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Hu01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Hu01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Hu01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Hu01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Hu01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Mu01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Mu01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Mu01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Mu01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Mu01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Ra01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Ra01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Ra01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Ra01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Ra01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Ca01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Ca01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Ca01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Ca01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Ca01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Po01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Po01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Po01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Po01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Po01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Bo01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Bo01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Bo01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Bo01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Bo01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Rb01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Rb01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Rb01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Rb01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Rb01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV034Mo01 | Recombinant Jagged 1 Protein (JAG1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV034Mo01 | Monoclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IP. |
| PAV034Mo01 | Polyclonal Antibody to Jagged 1 Protein (JAG1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV034Mo01 | CLIA Kit for Jagged 1 Protein (JAG1) | CLIA assay for Antigen Detection |
| ELV034Mo01 | ELISA Kit for Jagged 1 Protein (JAG1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12."
Genomics 43:376-379(1997) [PubMed] [Europe PMC] [Abstract]
"Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1."
Nat. Genet. 16:243-251(1997) [PubMed] [Europe PMC] [Abstract]
"The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1."
Immunity 8:43-55(1998) [PubMed] [Europe PMC] [Abstract]
"Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors."
EMBO J. 18:2803-2811(1999) [PubMed] [Europe PMC] [Abstract]
"Human ligands of the Notch receptor."
Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro."
J. Biol. Chem. 271:32499-32502(1996) [PubMed] [Europe PMC] [Abstract]
"Mutations in the human Jagged1 gene are responsible for Alagille syndrome."
Nat. Genet. 16:235-242(1997) [PubMed] [Europe PMC] [Abstract]
"JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype."
J. Med. Genet. 37:658-662(2000) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition."
Nat. Struct. Mol. Biol. 15:849-857(2008) [PubMed] [Europe PMC] [Abstract]
"Exon 6 of human JAG1 encodes a conserved structural unit."
BMC Struct. Biol. 9:43-43(2009) [PubMed] [Europe PMC] [Abstract]
"Spectrum and frequency of Jagged1 (JAG1) mutations in Alagille syndrome patients and their families."
Am. J. Hum. Genet. 62:1361-1369(1998) [PubMed] [Europe PMC] [Abstract]
"Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome."
Gastroenterology 116:1141-1148(1999) [PubMed] [Europe PMC] [Abstract]
"Jagged-1 mutation analysis in Italian Alagille syndrome patients."
Hum. Mutat. 14:394-400(1999) [PubMed] [Europe PMC] [Abstract]
"Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population."
Hum. Mutat. 16:408-416(2000) [PubMed] [Europe PMC] [Abstract]
"Familial tetralogy of Fallot caused by mutation in the Jagged1 gene."
Hum. Mol. Genet. 10:163-169(2001) [PubMed] [Europe PMC] [Abstract]
"Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome."
Hum. Mol. Genet. 10:405-413(2001) [PubMed] [Europe PMC] [Abstract]
"Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome."
Hum. Mutat. 17:72-73(2001) [PubMed] [Europe PMC] [Abstract]
"Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients."
Hum. Mutat. 17:151-152(2001) [PubMed] [Europe PMC] [Abstract]
"Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of Jagged 1."
Am. J. Hum. Genet. 71:180-186(2002) [PubMed] [Europe PMC] [Abstract]
"The significance of human Jagged 1 mutations detected in severe cases of extrahepatic biliary atresia."
Hepatology 36:904-912(2002) [PubMed] [Europe PMC] [Abstract]
"DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian Alagille syndrome patients."
Hum. Mutat. 20:481-481(2002) [PubMed] [Europe PMC] [Abstract]
"Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosage."
Am. J. Hum. Genet. 72:1065-1070(2003) [PubMed] [Europe PMC] [Abstract]
"Identification of 36 novel Jagged1 (JAG1) mutations in patients with Alagille syndrome."
Hum. Mutat. 21:100-100(2003) [PubMed] [Europe PMC] [Abstract]
"Twelve novel JAG1 gene mutations in Polish Alagille syndrome patients."
Hum. Mutat. 25:321-321(2005) [PubMed] [Europe PMC] [Abstract]
"Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate."
Hum. Mutat. 27:436-443(2006) [PubMed] [Europe PMC] [Abstract]
"Alagille Syndrome: A new missense mutation detected by whole-exome sequencing in a case previously found to be negative by DHPLC and MLPA."
Mol. Syndromol. 4:207-210(2013) [PubMed] [Europe PMC] [Abstract]