Nuclear Factor Kappa B (NFkB)

NF-KB1; EBP-1; KBF1; NF-Kappa-B; NFKB-P105; NFKB-P50; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; Nuclear factor NF-kappa-B p105 subunit

SPN	V017
HGNC	7794
MGI	97312
PubMed	15856292
RGD	70498
UniProt	P19838
Wiki	NFKB1

Nuclear factor NF-kappa-B p105 subunit isa 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex.

NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions.

Reference

"The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product."
Cell 62:1007-1018(1990) [PubMed] [Europe PMC] [Abstract]

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Nature 348:76-80(1990) [PubMed] [Europe PMC] [Abstract]

"Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha."
Proc. Natl. Acad. Sci. U.S.A. 88:966-970(1991) [PubMed] [Europe PMC] [Abstract]

"The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction."
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

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EMBO J. 11:205-213(1992) [PubMed] [Europe PMC] [Abstract]

"The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B."
Cell 78:773-785(1994) [PubMed] [Europe PMC] [Abstract]

"Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor."
Oncogene 9:1487-1492(1994) [PubMed] [Europe PMC] [Abstract]

"A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit."
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"Inhibition of NF-kappaB DNA binding by nitric oxide."
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"A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription."
Mol. Cell. Biol. 17:6184-6190(1997) [PubMed] [Europe PMC] [Abstract]

"Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome."
Cell 92:819-828(1998) [PubMed] [Europe PMC] [Abstract]

"NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes."
EMBO J. 18:4766-4778(1999) [PubMed] [Europe PMC] [Abstract]

"TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105."
Nature 397:363-368(1999) [PubMed] [Europe PMC] [Abstract]

"Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production."
EMBO J. 19:4712-4722(2000) [PubMed] [Europe PMC] [Abstract]

"RAC-3 is a NF-kappa B coactivator."
FEBS Lett. 485:195-199(2000) [PubMed] [Europe PMC] [Abstract]

"Inhibition of NF-kappaB by S-nitrosylation."
Biochemistry 40:1688-1693(2001) [PubMed] [Europe PMC] [Abstract]

"Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B."
Blood 98:743-753(2001) [PubMed] [Europe PMC] [Abstract]

"15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit."
J. Biol. Chem. 276:35530-35536(2001) [PubMed] [Europe PMC] [Abstract]

"Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis."
J. Biol. Chem. 276:22215-22222(2001) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."
Oncogene 20:4917-4925(2001) [PubMed] [Europe PMC] [Abstract]

"Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105."
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"Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins."
J. Biol. Chem. 277:4973-4980(2002) [PubMed] [Europe PMC] [Abstract]

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Blood 101:729-738(2003) [PubMed] [Europe PMC] [Abstract]

"Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation."
J. Biol. Chem. 278:4770-4777(2003) [PubMed] [Europe PMC] [Abstract]

"Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability."
J. Biol. Chem. 278:39583-39590(2003) [PubMed] [Europe PMC] [Abstract]

"betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932."
Mol. Cell. Biol. 23:402-413(2003) [PubMed] [Europe PMC] [Abstract]

"Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB."
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"ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]

"Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages: involvement in cytokine synthesis."
Infect. Immun. 72:2582-2589(2004) [PubMed] [Europe PMC] [Abstract]

"Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105."
Mol. Cell. Biol. 24:9658-9667(2004) [PubMed] [Europe PMC] [Abstract]

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Nat. Cell Biol. 6:97-105(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 373:311-317(1995) [PubMed] [Europe PMC] [Abstract]

"Structure of an IkappaBalpha/NF-kappaB complex."
Cell 95:749-758(1998) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the death domain in human nuclear factor NF-kappa-B p105 subunit."
Submitted (DEC-2006) to the PDB data bank