Call Now

Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2)

  • ROCK2 is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos  serum response element. ROCK2, which is an isozyme of ROCK1, is a target for the small GTPase Rho.

  • By screening human brain cDNAs for the potential to encode proteins larger than 50 kD, Ishikawa et al. (1998) identified a ROCK2 cDNA, which they called KIAA0619. RT-PCR detected ROCK2 expression in all human tissues examined.By PCR of human cDNA using oligonucleotides based on the sequence of a bovine ROCK2 cDNA, followed by screening of a human brain cDNA library, Takahashi et al. (1999) isolated a human ROCK2 cDNA.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Hu01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Hu01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Hu01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Hu01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Hu01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Mu01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Mu01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Mu01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Mu01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Mu01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Ra01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Ra01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Ra01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Ra01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Ra01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Ca01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Ca01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Ca01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Ca01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Ca01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Po01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Po01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Po01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Po01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Po01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Bo01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Bo01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Bo01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Bo01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Bo01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Rb01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Rb01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Rb01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Rb01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Rb01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU988Mo01 Recombinant Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU988Mo01 Monoclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IP.
PAU988Mo01 Polyclonal Antibody to Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) WB; IHC; ICC; IF.
Assay Kits CLU988Mo01 CLIA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) CLIA assay for Antigen Detection
ELU988Mo01 ELISA Kit for Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24."
Genomics 55:235-237(1999) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo."
J. Cell Biol. 147:1023-1038(1999) [PubMed] [Europe PMC] [Abstract]

"Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner."
J. Exp. Med. 201:465-471(2005) [PubMed] [Europe PMC] [Abstract]

"Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase."
J. Biol. Chem. 281:15320-15329(2006) [PubMed] [Europe PMC] [Abstract]

"Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication."
Mol. Cell. Biol. 26:9016-9034(2006) [PubMed] [Europe PMC] [Abstract]

"Regulation of RhoA-dependent ROCKII activation by Shp2."
J. Cell Biol. 181:999-1012(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells."
Circ. Res. 104:531-540(2009) [PubMed] [Europe PMC] [Abstract]

"Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation."
PLoS ONE 4:E8190-E8190(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis."
Dev. Cell 18:486-495(2010) [PubMed] [Europe PMC] [Abstract]

"Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics."
J. Cell Sci. 123:3368-3377(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2."
Cancer Res. 71:68-77(2011) [PubMed] [Europe PMC] [Abstract]

"Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production."
J. Biol. Chem. 286:6117-6127(2011) [PubMed] [Europe PMC] [Abstract]

"Rocks: multifunctional kinases in cell behaviour."
Nat. Rev. Mol. Cell Biol. 4:446-456(2003) [PubMed] [Europe PMC] [Abstract]

"Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity."
Cytoskeleton 67:545-554(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]