Cyclin Dependent Kinase 7 (CDK7)
CAK1; CDKN7; STK1; MO15; 39 kDa protein kinase; Serine/threonine-protein kinase 1; Cell Division Protein Kinase 7; TFIIH basal transcription factor complex kinase subunit
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Hu01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Hu01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Hu01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Hu01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Hu01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Mu01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Mu01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Mu01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Mu01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Mu01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Ra01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Ra01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Ra01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Ra01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Ra01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Ca01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Ca01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Ca01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Ca01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Ca01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Po01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Po01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Po01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Po01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Po01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Bo01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Bo01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Bo01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Bo01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Bo01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Rb01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Rb01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Rb01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Rb01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Rb01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU961Mo01 | Recombinant Cyclin Dependent Kinase 7 (CDK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU961Mo01 | Monoclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IP. |
| PAU961Mo01 | Polyclonal Antibody to Cyclin Dependent Kinase 7 (CDK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU961Mo01 | CLIA Kit for Cyclin Dependent Kinase 7 (CDK7) | CLIA assay for Antigen Detection |
| ELU961Mo01 | ELISA Kit for Cyclin Dependent Kinase 7 (CDK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)."
J. Cell Biol. 127:467-478(1994) [PubMed] [Europe PMC] [Abstract]
"Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern."
Oncogene 9:1977-1988(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase."
Oncogene 9:3127-3138(1994) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase."
Oncogene 9:2089-2096(1994) [PubMed] [Europe PMC] [Abstract]
"Human and Xenopus MO15 mRNA are highly conserved but show different patterns of expression in adult tissues."
Oncol. Rep. 1:1269-1275(1994)
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase."
Cell 78:713-724(1994) [PubMed] [Europe PMC] [Abstract]
"p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner."
Mol. Cell. Biol. 17:7220-7229(1997) [PubMed] [Europe PMC] [Abstract]
"The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7."
Genes Dev. 12:3541-3550(1998) [PubMed] [Europe PMC] [Abstract]
"Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes."
J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]
"Regulation of CAK kinase activity by p53."
Oncogene 17:2733-2741(1998) [PubMed] [Europe PMC] [Abstract]
"Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7."
Mol. Cell 3:87-95(1999) [PubMed] [Europe PMC] [Abstract]
"The FBP interacting repressor targets TFIIH to inhibit activated transcription."
Mol. Cell 5:331-341(2000) [PubMed] [Europe PMC] [Abstract]
"Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop."
Mol. Cell. Biol. 21:88-99(2001) [PubMed] [Europe PMC] [Abstract]
"Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells."
Tissue Cell 37:53-58(2005) [PubMed] [Europe PMC] [Abstract]
"Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics."
Nat. Struct. Mol. Biol. 13:55-62(2006) [PubMed] [Europe PMC] [Abstract]
"Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells."
Mol. Cell 25:839-850(2007) [PubMed] [Europe PMC] [Abstract]
"Recognition of Cdk2 by Cdk7."
Proteins 67:1048-1059(2007) [PubMed] [Europe PMC] [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7."
Mol. Endocrinol. 22:91-104(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II."
Mol. Cell 34:387-393(2009) [PubMed] [Europe PMC] [Abstract]
"SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation."
Mol. Cell. Biol. 29:613-625(2009) [PubMed] [Europe PMC] [Abstract]
"TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II."
Mol. Cell. Biol. 29:5455-5464(2009) [PubMed] [Europe PMC] [Abstract]
"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation."
Nucleic Acids Res. 37:1260-1268(2009) [PubMed] [Europe PMC] [Abstract]
"DNA-Bound peptides control the mRNA transcription through CDK7."
Peptides 30:681-688(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition."
J. Biol. Chem. 285:16978-16990(2010) [PubMed] [Europe PMC] [Abstract]
"R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis."
J. Cell. Biochem. 109:217-235(2010) [PubMed] [Europe PMC] [Abstract]
"CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?"
Cell Cycle 4:572-577(2005) [PubMed] [Europe PMC] [Abstract]
"Cell cycle, CDKs and cancer: a changing paradigm."
Nat. Rev. Cancer 9:153-166(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A history of TFIIH: Two decades of molecular biology on a pivotal transcription/repair factor."
DNA Repair 10:714-721(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of human CDK7 and its protein recognition properties."
Structure 12:2067-2079(2004) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]