Protein S (PROS)
PSA; PS; PS26; PS21; PS22; PS23; PS24; PS25; VKDPS; VKDP-S; Protein Sa; Vitamin K Dependent Protein S
Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. The best characterized function of Protein S is its role in the anti coagulation pathway, it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa. Only the free form has cofactor activity.
Protein S can bind to negatively charged phospholipids via the carboxylated GLA domain. This property allows Protein S to function in the removal of cells which are undergoing apoptosis. Apoptosis is a form of cell death that is used by the body to remove unwanted or damaged cells from tissues.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Hu01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Hu01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Hu01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Hu01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Hu01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Mu01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Mu01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Mu01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Mu01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Mu01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Ra01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Ra01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Ra01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Ra01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Ra01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Ca01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Ca01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Ca01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Ca01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Ca01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Po01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Po01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Po01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Po01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Po01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Bo01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Bo01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Bo01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Bo01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Bo01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Rb01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Rb01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Rb01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Rb01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Rb01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU871Mo01 | Recombinant Protein S (PROS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU871Mo01 | Monoclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IP. |
| PAU871Mo01 | Polyclonal Antibody to Protein S (PROS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU871Mo01 | CLIA Kit for Protein S (PROS) | CLIA assay for Antigen Detection |
| ELU871Mo01 | ELISA Kit for Protein S (PROS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing."
FEBS Lett. 222:186-190(1987) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of human liver cDNA encoding a protein S precursor."
Proc. Natl. Acad. Sci. U.S.A. 84:349-353(1987) [PubMed] [Europe PMC] [Abstract]
"Organization of the human protein S genes."
Biochemistry 29:7845-7852(1990) [PubMed] [Europe PMC] [Abstract]
"Intron-exon organization of the active human protein S gene PS alpha and its pseudogene PS beta: duplication and silencing during primate evolution."
Biochemistry 29:7853-7861(1990) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation."
Proc. Natl. Acad. Sci. U.S.A. 83:6716-6720(1986) [PubMed] [Europe PMC] [Abstract]
"Identification of eight point mutations in protein S deficiency type I -- analysis of 15 pedigrees."
Thromb. Haemost. 73:750-755(1995) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the Ca2+-binding EGF3-4 pair from vitamin K-dependent protein S: identification of an unusual fold in EGF3."
Biochemistry 44:8782-8789(2005) [PubMed] [Europe PMC] [Abstract]
"Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460."
Blood 76:538-548(1990) [PubMed] [Europe PMC] [Abstract]
Unpublished observations (SEP-1993)
"Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S."
Blood 83:683-690(1994) [PubMed] [Europe PMC] [Abstract]
"Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene."
Blood 85:130-138(1995) [PubMed] [Europe PMC] [Abstract]
"Detection and characterization of seven novel protein S (PROS) gene lesions: evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy."
Blood 86:2632-2641(1995) [PubMed] [Europe PMC] [Abstract]
"Protein S deficiency type I: identification of point mutations in 9 of 10 families."
Blood 86:3444-3451(1995) [PubMed] [Europe PMC] [Abstract]
"Identification of two novel point mutations in the human protein S gene associated with familial protein S deficiency and thrombosis."
Arterioscler. Thromb. Vasc. Biol. 16:1407-1415(1996) [PubMed] [Europe PMC] [Abstract]
"Molecular basis of a hereditary type I protein S deficiency caused by a substitution of Cys for Arg474."
Blood 87:4643-4650(1996) [PubMed] [Europe PMC] [Abstract]
"Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V Leiden."
Blood 88:1700-1707(1996) [PubMed] [Europe PMC] [Abstract]
"Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis."
Blood 88:4195-4204(1996) [PubMed] [Europe PMC] [Abstract]
"Molecular basis for protein S hereditary deficiency: genetic defects observed in 118 patients with type I and type IIa deficiencies."
J. Lab. Clin. Med. 128:218-227(1996) [PubMed] [Europe PMC] [Abstract]
"Five novel mutations of the protein S active gene (PROS 1) in 8 Norman families."
Thromb. Haemost. 75:437-444(1996) [PubMed] [Europe PMC] [Abstract]
"Identification of three novel mutations in hereditary protein S deficiency."
Thromb. Haemost. 77:21-25(1997) [PubMed] [Europe PMC] [Abstract]
"Protein S deficiency: a database of mutations."
Thromb. Haemost. 77:1201-1214(1997) [PubMed] [Europe PMC] [Abstract]
"Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency."
Hum. Mutat. 14:30-39(1999) [PubMed] [Europe PMC] [Abstract]
"Poor relationship between phenotypes of protein S deficiency and mutations in the protein S alpha gene."
Thromb. Haemost. 82:1634-1638(1999) [PubMed] [Europe PMC] [Abstract]
"Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S."
Blood 95:1935-1941(2000) [PubMed] [Europe PMC] [Abstract]
"Optimization of a simple and rapid single-strand conformation analysis for detection of mutations in the PROS1 gene: identification of seven novel mutations and three novel, apparently neutral, variants."
Hum. Mutat. 15:463-473(2000) [PubMed] [Europe PMC] [Abstract]
"DNA sequence analysis of protein S deficiency -- identification of four point mutations in twelve Japanese subjects."
Semin. Thromb. Hemost. 27:155-160(2001) [PubMed] [Europe PMC] [Abstract]
"Characterization and structural impact of five novel PROS1 mutations in eleven protein S-deficient families."
Thromb. Haemost. 86:1392-1399(2001) [PubMed] [Europe PMC] [Abstract]
"Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency."
Blood 100:2812-2819(2002) [PubMed] [Europe PMC] [Abstract]
"Genetic and phenotypic variability between families with hereditary protein S deficiency."
Thromb. Haemost. 87:258-265(2002) [PubMed] [Europe PMC] [Abstract]
"Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S."
Thromb. Res. 105:233-239(2002) [PubMed] [Europe PMC] [Abstract]
"Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations."
Blood Coagul. Fibrinolysis 14:191-196(2003) [PubMed] [Europe PMC] [Abstract]
"Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency."
Br. J. Haematol. 126:219-225(2004) [PubMed] [Europe PMC] [Abstract]
"Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study."
Hum. Mutat. 25:259-269(2005) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
"Intracerebral mass bleeding in a term neonate: manifestation of hereditary protein S deficiency with a new mutation in the PROS1 gene."
Neonatology 98:337-340(2010) [PubMed] [Europe PMC] [Abstract]