Interleukin 4 Receptor (IL4R)
CD124; IL4-R; IL4RA; IL4-BP; Soluble interleukin-4 receptor subunit alpha; IL-4-binding protein
Interleukin 4 receptor is the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells.
Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Hu01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Hu01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Hu01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Hu01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Hu01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Mu01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Mu01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Mu01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Mu01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Mu01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Ra01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Ra01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Ra01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Ra01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Ra01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Ca01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Ca01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Ca01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Ca01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Ca01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Po01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Po01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Po01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Po01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Po01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Bo01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Bo01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Bo01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Bo01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Bo01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Rb01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Rb01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Rb01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Rb01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Rb01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU812Mo01 | Recombinant Interleukin 4 Receptor (IL4R) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU812Mo01 | Monoclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IP. |
| PAU812Mo01 | Polyclonal Antibody to Interleukin 4 Receptor (IL4R) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU812Mo01 | CLIA Kit for Interleukin 4 Receptor (IL4R) | CLIA assay for Antigen Detection |
| ELU812Mo01 | ELISA Kit for Interleukin 4 Receptor (IL4R) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily."
J. Exp. Med. 171:861-873(1990) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of a cDNA encoding the human interleukin 4 receptor."
Int. Immunol. 2:669-675(1990) [PubMed] [Europe PMC] [Abstract]
"Characterization of the membrane-bound and a soluble form of human IL-4 receptor alpha produced by alternative splicing."
Int. Immunol. 11:1965-1970(1999) [PubMed] [Europe PMC] [Abstract]
"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel single-nucleotide polymorphism (Val554Ile) and definition of eight common alleles for human IL4RA exon 11."
Tissue Antigens 57:216-220(2001) [PubMed] [Europe PMC] [Abstract]
"An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth."
Cell 76:811-820(1994) [PubMed] [Europe PMC] [Abstract]
"Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha."
J. Biol. Chem. 270:9630-9637(1995) [PubMed] [Europe PMC] [Abstract]
"The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor."
J. Biol. Chem. 270:13869-13878(1995) [PubMed] [Europe PMC] [Abstract]
"JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering."
Oncogene 10:1757-1761(1995) [PubMed] [Europe PMC] [Abstract]
"IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells."
FEBS Lett. 393:53-56(1996) [PubMed] [Europe PMC] [Abstract]
"Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor."
Immunity 4:123-132(1996) [PubMed] [Europe PMC] [Abstract]
"Soluble human interleukin-4 receptor is produced by activated T cells under the control of metalloproteinases."
Int. Arch. Allergy Immunol. 119:23-30(1999) [PubMed] [Europe PMC] [Abstract]
"Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation."
J. Immunol. 167:6382-6387(2001) [PubMed] [Europe PMC] [Abstract]
"The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters."
J. Mol. Biol. 315:399-407(2002) [PubMed] [Europe PMC] [Abstract]
"Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome."
J. Biol. Chem. 278:3903-3911(2003) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface."
Cell 97:271-281(1999) [PubMed] [Europe PMC] [Abstract]
"Common polymorphisms in the coding part of the IL4-receptor gene."
Biochem. Biophys. Res. Commun. 231:696-697(1997) [PubMed] [Europe PMC] [Abstract]
"The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor."
N. Engl. J. Med. 337:1720-1725(1997) [PubMed] [Europe PMC] [Abstract]
"Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma."
Nat. Genet. 19:119-120(1998) [PubMed] [Europe PMC] [Abstract]
"No association between atopy/asthma and the Ile50Val polymorphism of IL-4 receptor."
Am. J. Respir. Crit. Care Med. 160:342-345(1999) [PubMed] [Europe PMC] [Abstract]
"The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction."
Immunology 96:365-371(1999) [PubMed] [Europe PMC] [Abstract]
"Effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction."
J. Immunol. 162:4385-4389(1999) [PubMed] [Europe PMC] [Abstract]
"Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations."
Am. J. Hum. Genet. 66:517-526(2000) [PubMed] [Europe PMC] [Abstract]
"Interleukin 4 receptor alpha chain polymorphism Gln551Arg is associated with adult atopic dermatitis in Japan."
Br. J. Dermatol. 142:1003-1006(2000) [PubMed] [Europe PMC] [Abstract]
"Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences."
Clin. Immunol. 100:298-304(2001) [PubMed] [Europe PMC] [Abstract]
"High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis."
J. Allergy Clin. Immunol. 112:1127-1131(2003) [PubMed] [Europe PMC] [Abstract]