Histone Deacetylase 2 (HDAC2)

RPD3; YAF1; HD2

SPN	U634
HGNC	4853
MGI	1097691
PubMed	22492270
RGD	619976
UniProt	Q92769
Wiki	HDAC2

Histone deacetylase 2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.

YY1 is a mammalian zinc finger transcription factor that acts as both a positive and negative regulator of transcription at CCATNTT consensus DNA elements in promoters of cellular and viral genes.

Reference

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