Embryonic Ectoderm Development (EED)

HEED; WAIT1; WD Protein Associating With Integrin Cytoplasmic Tails 1

SPN	U632
HGNC	3188
MGI	95286
PubMed	21497788
RGD	1309782
UniProt	O75530
Wiki	EED

Polycomb protein EED is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus.

Reference

"The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation."
Genomics 54:79-88(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes."
Mol. Cell. Biol. 18:3586-3595(1998) [PubMed] [Europe PMC] [Abstract]

"HEED, the product of the human homolog of the murine eed gene, binds to the matrix protein of HIV-1."
J. Biol. Chem. 274:1635-1645(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins."
J. Biol. Chem. 273:27459-27466(1998) [PubMed] [Europe PMC] [Abstract]

"Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation."
Nat. Genet. 23:474-478(1999) [PubMed] [Europe PMC] [Abstract]

"The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos."
Mol. Cell. Biol. 21:1360-1369(2001) [PubMed] [Europe PMC] [Abstract]

"Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein."
Genes Dev. 16:2893-2905(2002) [PubMed] [Europe PMC] [Abstract]

"Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins."
Mol. Cell. Biol. 22:5539-5553(2002) [PubMed] [Europe PMC] [Abstract]

"Role of histone H3 lysine 27 methylation in Polycomb-group silencing."
Science 298:1039-1043(2002) [PubMed] [Europe PMC] [Abstract]

"EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer."
EMBO J. 22:5323-5335(2003) [PubMed] [Europe PMC] [Abstract]

"Role of histone H3 lysine 27 methylation in X inactivation."
Science 300:131-135(2003) [PubMed] [Europe PMC] [Abstract]

"Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity."
EMBO J. 23:4061-4071(2004) [PubMed] [Europe PMC] [Abstract]

"Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27."
Genes Dev. 18:1592-1605(2004) [PubMed] [Europe PMC] [Abstract]

"Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3."
Mol. Cell 14:183-193(2004) [PubMed] [Europe PMC] [Abstract]

"SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex."
Mol. Cell 15:57-67(2004) [PubMed] [Europe PMC] [Abstract]

"Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation."
Proc. Natl. Acad. Sci. U.S.A. 102:1859-1864(2005) [PubMed] [Europe PMC] [Abstract]

"Substrate preferences of the EZH2 histone methyltransferase complex."
J. Biol. Chem. 281:8365-8370(2006) [PubMed] [Europe PMC] [Abstract]

"The Polycomb group protein EZH2 directly controls DNA methylation."
Nature 439:871-874(2006) [PubMed] [Europe PMC] [Abstract]

Erratum
Nature 446:824-824(2007)

"Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer."
Nat. Genet. 39:232-236(2007) [PubMed] [Europe PMC] [Abstract]

"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms."
Mol. Cell 32:503-518(2008) [PubMed] [Europe PMC] [Abstract]

"Role of hPHF1 in H3K27 methylation and Hox gene silencing."
Mol. Cell. Biol. 28:1862-1872(2008) [PubMed] [Europe PMC] [Abstract]

"Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo."
Mol. Cell. Biol. 28:2718-2731(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27."
J. Biol. Chem. 286:42414-42425(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)."
Proc. Natl. Acad. Sci. U.S.A. 107:19266-19271(2010) [PubMed] [Europe PMC] [Abstract]