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Erythrocyte Membrane Protein Band 4.1 (EPB41)

EL1; EPB41; 4.1R; HE; Elliptocytosis 1,RH-linked

Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton.

The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene , the beta-spectrin gene , or the band 3 gene .Band 4.1 is a protein associated with the cytoskeleton of the red blood cell.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Hu01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Hu01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Hu01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Hu01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Hu01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Mu01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Mu01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Mu01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Mu01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Mu01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Ra01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Ra01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Ra01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Ra01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Ra01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Ca01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Ca01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Ca01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Ca01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Ca01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Po01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Po01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Po01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Po01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Po01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Bo01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Bo01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Bo01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Bo01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Bo01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Rb01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Rb01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Rb01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Rb01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Rb01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU581Mo01 Recombinant Erythrocyte Membrane Protein Band 4.1 (EPB41) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU581Mo01 Monoclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IP.
PAU581Mo01 Polyclonal Antibody to Erythrocyte Membrane Protein Band 4.1 (EPB41) WB; IHC; ICC; IF.
Assay Kits CLU581Mo01 CLIA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) CLIA assay for Antigen Detection
ELU581Mo01 ELISA Kit for Erythrocyte Membrane Protein Band 4.1 (EPB41) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1."
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"Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells."
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"Identification of two cAMP-dependent phosphorylation sites on erythrocyte protein 4.1."
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"Structure of the spectrin-actin binding site of erythrocyte protein 4.1."
J. Biol. Chem. 261:13362-13366(1986) [PubMed] [Europe PMC] [Abstract]

"O-N-acetyl-D-glucosamine moiety on discrete peptide of multiple protein 4.1 isoforms regulated by alternative pathways."
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"Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro."
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"Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1."
Proc. Natl. Acad. Sci. U.S.A. 91:9818-9822(1994) [PubMed] [Europe PMC] [Abstract]

"Ca(2+)-dependent and Ca(2+)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins."
J. Biol. Chem. 275:6360-6367(2000) [PubMed] [Europe PMC] [Abstract]

"Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex."
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"Properties of the C-terminal domain of 4.1 proteins."
Eur. J. Biochem. 268:3709-3717(2001) [PubMed] [Europe PMC] [Abstract]

"An alternative domain containing a leucine-rich sequence regulates nuclear cytoplasmic localization of protein 4.1R."
J. Biol. Chem. 278:2686-2691(2003) [PubMed] [Europe PMC] [Abstract]

"Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase."
Mol. Biol. Cell 16:117-127(2005) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization."
Nat. Struct. Biol. 7:871-875(2000) [PubMed] [Europe PMC] [Abstract]