Calcium And Integrin Binding Protein 1 (CIB1)

CIB; KIP; SIP2-28; CIBP; PRKDCIP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; SNK-interacting protein 2-28

SPN	U467
HGNC	16920
MGI	1344418
PubMed	20639889
RGD	620133
UniProt	Q99828
Wiki	CIB1

Calcium and integrin-binding protein 1 is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).Gel filtration and sedimentation equilibrium analyses showed that only a small percentage of CIB1 formed dimers, with most CIB1 remaining monomeric in the presence or absence of Ca(2+). The calculated molecular mass of CIB1 is 21.7 kD, but the protein had an apparent molecular mass of either 26.9 or 30.6 kD, depending on the method used, most likely due to its irregular shape.

Reference

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J. Biol. Chem. 272:4651-4654(1997) [PubMed] [Europe PMC] [Abstract]

"Interaction between DNA-dependent protein kinase and a novel protein, KIP."
Mutat. Res. 385:13-20(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP)."
DNA Seq. 10:415-418(2000) [PubMed] [Europe PMC] [Abstract]

"A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis."
Oncogene 33:1167-1180(2014) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton."
Biochem. J. 342:729-735(1999) [PubMed] [Europe PMC] [Abstract]

"A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein."
J. Cell Biol. 145:1277-1292(1999) [PubMed] [Europe PMC] [Abstract]

"The interaction of the calcium- and integrin-binding protein (CIBP) with the coagulation factor VIII."
Thromb. Res. 102:177-185(2001) [PubMed] [Europe PMC] [Abstract]

"NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube."
Eur. J. Biochem. 269:538-545(2002) [PubMed] [Europe PMC] [Abstract]

"The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading."
J. Biol. Chem. 277:8321-8328(2002) [PubMed] [Europe PMC] [Abstract]

"EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response."
J. Biol. Chem. 277:26468-26478(2002) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain."
J. Biol. Chem. 277:28877-28883(2002) [PubMed] [Europe PMC] [Abstract]

"Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen."
Blood 102:1355-1362(2003) [PubMed] [Europe PMC] [Abstract]

"Metal ion binding properties and conformational states of calcium- and integrin-binding protein."
Biochemistry 43:2558-2568(2004) [PubMed] [Europe PMC] [Abstract]

"Calcium binding sequences in calmyrin regulates interaction with presenilin-2."
Exp. Cell Res. 300:440-454(2004) [PubMed] [Europe PMC] [Abstract]

"Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen."
Blood 102:3629-3636(2003) [PubMed] [Europe PMC] [Abstract]

"Calcium-binding calmyrin forms stable covalent dimers in vitro, but in vivo is found in monomeric form."
Acta Biochim. Pol. 52:469-476(2005) [PubMed] [Europe PMC] [Abstract]

"G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell."
Cancer Immunol. Immunother. 54:729-740(2005) [PubMed] [Europe PMC] [Abstract]

"Essential role of CIB1 in regulating PAK1 activation and cell migration."
J. Cell Biol. 170:465-476(2005) [PubMed] [Europe PMC] [Abstract]

"Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin alphaIIb cytoplasmic domain."
Protein Sci. 14:1429-1437(2005) [PubMed] [Europe PMC] [Abstract]

"CIB1, a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channel."
J. Biol. Chem. 281:20825-20833(2006) [PubMed] [Europe PMC] [Abstract]

"CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation."
J. Cell Biol. 172:169-175(2006) [PubMed] [Europe PMC] [Abstract]

"Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3-dependent Ca2+ release in vivo."
J. Neurochem. 106:2249-2262(2008) [PubMed] [Europe PMC] [Abstract]

"CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1."
Proc. Natl. Acad. Sci. U.S.A. 106:17389-17394(2009) [PubMed] [Europe PMC] [Abstract]

"Auxiliary Ca2+ binding sites can influence the structure of CIB1."
Protein Sci. 18:1128-1134(2009) [PubMed] [Europe PMC] [Abstract]

"Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1."
J. Biol. Chem. 285:483-492(2010) [PubMed] [Europe PMC] [Abstract]

"CIB1 is a regulator of pathological cardiac hypertrophy."
Nat. Med. 16:872-879(2010) [PubMed] [Europe PMC] [Abstract]

"Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth."
Biochim. Biophys. Acta 1813:1025-1037(2011) [PubMed] [Europe PMC] [Abstract]

"Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression."
Int. J. Biochem. Cell Biol. 43:120-129(2011) [PubMed] [Europe PMC] [Abstract]

"Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells."
Int. J. Cancer 128:587-596(2011) [PubMed] [Europe PMC] [Abstract]

"Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling."
J. Cell. Biochem. 112:3289-3299(2011) [PubMed] [Europe PMC] [Abstract]

"Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells."
PLoS ONE 6:E14513-E14513(2011) [PubMed] [Europe PMC] [Abstract]

"Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences."
Biochem. Cell Biol. 90:646-656(2012) [PubMed] [Europe PMC] [Abstract]

"Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity."
Biochemistry 52:7082-7090(2013) [PubMed] [Europe PMC] [Abstract]

"CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling."
Oncogene 32:4017-4027(2013) [PubMed] [Europe PMC] [Abstract]

"Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies."
J. Mol. Recognit. 13:83-92(2000) [PubMed] [Europe PMC] [Abstract]

"Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins."
J. Biol. Chem. 280:8407-8415(2005) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions."
Protein Sci. 14:1214-1221(2005) [PubMed] [Europe PMC] [Abstract]

"Solution structures of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain."
J. Biol. Chem. 286:17181-17192(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the activation of platelet integrin alphaIIbbeta3 by calcium- and integrin-binding protein 1."
J. Am. Chem. Soc. 134:3864-3872(2012) [PubMed] [Europe PMC] [Abstract]