Cartilage Intermediate Layer Protein (CILP)

Nucleotide Pyrophosphohydrolase; Cartilage intermediate-layer protein

SPN	U466
HGNC	1980
MGI	2444507
PubMed	12483726
RGD	1305124
UniProt	O75339
Wiki	CILP

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly.

Reference

"Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase."
J. Biol. Chem. 273:23469-23475(1998) [PubMed] [Europe PMC] [Abstract]

"Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP)."
J. Hum. Genet. 44:203-205(1999) [PubMed] [Europe PMC] [Abstract]

"The human CILP gene: exon/intron organization and chromosomal mapping."
Matrix Biol. 18:445-454(1999) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age."
J. Biol. Chem. 273:23463-23468(1998) [PubMed] [Europe PMC] [Abstract]

"Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease."
Arthritis Rheum. 46:3218-3229(2002) [PubMed] [Europe PMC] [Abstract]

"Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis."
Arthritis Rheum. 44:838-845(2001) [PubMed] [Europe PMC] [Abstract]

"One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist."
Arthritis Rheum. 48:1302-1314(2003) [PubMed] [Europe PMC] [Abstract]

"Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice."
Ann. Rheum. Dis. 63:252-258(2004) [PubMed] [Europe PMC] [Abstract]

"The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes."
Rheumatol. Int. 26:35-41(2005) [PubMed] [Europe PMC] [Abstract]

"A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease."
Nat. Genet. 37:607-612(2005) [PubMed] [Europe PMC] [Abstract]

"Diagnostic exome sequencing in persons with severe intellectual disability."
N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]